137030
二乙基-1,4-二氢-2,4,6-三甲基-3,5-吡啶二羧酸酯
99%
别名:
3，5-二乙酯基-1，4-, DDC
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关于此项目
经验公式（希尔记法）:
C14H21NO4
化学文摘社编号:
分子量:
267.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
211-188-0
MDL number:
产品名称
二乙基-1,4-二氢-2,4,6-三甲基-3,5-吡啶二羧酸酯, 99%
InChI key
CDVAIHNNWWJFJW-UHFFFAOYSA-N
InChI
1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3
SMILES string
CCOC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCC
assay
99%
form
powder
mp
130-132 °C (lit.)
Quality Level
Application
在小鼠中，1，4-二氢-2，4，6-三甲基-3，5-吡啶二甲酸二乙酯在体内诱导 Mallory-Denk体形成。
Biochem/physiol Actions
在小鼠中，1，4-二氢-2，4，6-三甲基-3，5-吡啶二甲酸二乙酯阻断血红素合成，并防止诱导产生肝脏血红素加氧酶-1。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Volker Mostert et al.
Drug metabolism reviews, 39(2-3), 619-626 (2007-09-06)
Heme oxygenase (HO)-1 is induced by oxidative stress and protects against oxidant injury. We examined the effect of rapid induction of hepatic HO-1 on serum iron level. Serum iron was approximately doubled within 6 h when HO-1 was induced by
Pavel Strnad et al.
Hepatology (Baltimore, Md.), 48(3), 931-942 (2008-08-13)
The cytoplasmic hepatocyte inclusions, Mallory-Denk bodies (MDBs), are characteristic of several liver disorders, including alcoholic and nonalcoholic steatohepatitis. In mice, MDBs can be induced by long-term feeding with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) for 3 to 4 months or rapidly reformed in DDC-induced
Johanna R Schaub et al.
Nature, 557(7704), 247-251 (2018-05-04)
Transdifferentiation is a complete and stable change in cell identity that serves as an alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of transdifferentiation have been limited to the replenishment of cells lost from preexisting structures, in the presence
Tohru Itoh et al.
FEBS letters, 583(4), 777-781 (2009-01-29)
In injured livers where hepatocyte growth is severely limited, facultative hepatic stem/progenitor cells, termed oval cells in rodents, are known to emerge and contribute to the regeneration process. Here, we investigated a possible involvement of Wnt signaling during mouse oval
Leila Jemail et al.
Scientific reports, 8(1), 6415-6415 (2018-04-25)
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown. We aimed to investigate the precise roles of KCs in
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