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Merck
CN

134910

Sigma-Aldrich

(1R,2S)-(-)-麻黄碱

98%

别名:

(-)-麻黄碱, (1R,2S)-(-)-α-(1-甲基氨基乙基)苄醇, (1R,2S)-(-)-2-甲氨基-1-苯丙醇, L-盐酸麻黄碱

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About This Item

线性分子式:
C6H5CH[CH(NHCH3)CH3]OH
CAS号:
分子量:
165.23
Beilstein:
2208730
EC 号:
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

98%

形式

solid

旋光性

[α]21/D −41°, c = 5 in 1 M HCl

bp

255 °C (lit.)

mp

37-39 °C (lit.)

密度

1.124 g/mL at 25 °C (lit.)

储存温度

2-8°C

SMILES字符串

CN[C@@H](C)[C@H](O)c1ccccc1

InChI

1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1

InChI key

KWGRBVOPPLSCSI-WPRPVWTQSA-N

一般描述

(1R,2S)-(-)-Ephedrine, a chiral β-amino alcohol, is commonly used as a chiral auxiliary in asymmetric synthesis. It undergoes reduction to form (+)-methamphetamine.

应用

通用手性合成子,用于催化以及制备光学纯亚砜和噁唑烷。
(1R,2S)-(-)-Ephedrine can be used in the preparation of optically active phosphine-phosphonite ligands and chirally-substituted cyclopentadienyl (Cp) ligands. It reacts with phosphorus trichloride to form (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine. It can also act as a chiral resolving agent for (±)-mandelic acid.

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1B

WGK

WGK 1

闪点(°F)

186.8 °F

闪点(°C)

86 °C

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Synthetic Communications, 829-829 (1992)
Tetrahedron Asymmetry, 2, 1123-1123 (1991)
A novel chiral cyclopentadienyl ligand based on ephedrine
van der Zeijden AAH
Tetrahedron Asymmetry, 6(4), 913-918 (1995)
(1R,2S)-Ephedrine
Soai K and Hitchcock SR
e-EROS Encyclopedia of Reagents for Organic Synthesis. null
Investigation of (1R, 2S)-(-)-Ephedrine by Cryogenic Terahertz Spectroscopy and Solid-State Density Functional Theory.
Hakey PM, et al
ChemPhysChem, 10(14), 2434-2444 (2009)

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