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Merck
CN

133973

Sigma-Aldrich

溴乙酸乙酯

reagent grade, 98%

别名:

Bromoacetic acid ethyl ester, Ethyl 2-bromoacetate

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About This Item

线性分子式:
BrCH2COOC2H5
CAS号:
分子量:
167.00
Beilstein:
506456
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

等级

reagent grade

质量水平

蒸汽压

2.6 mmHg ( 25 °C)

方案

98%

表单

liquid

折射率

n20/D 1.451 (lit.)

沸点

159 °C (lit.)

溶解性

water: insoluble

密度

1.506 g/mL at 25 °C (lit.)

官能团

bromo
ester

SMILES字符串

CCOC(=O)CBr

InChI

1S/C4H7BrO2/c1-2-7-4(6)3-5/h2-3H2,1H3

InChI key

PQJJJMRNHATNKG-UHFFFAOYSA-N

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一般描述

溴代乙酸乙酯常在有机合成中用作为烷化剂和酰化试剂。溴代乙酸乙酯与叔丁基杯[4]芳烃进行衍生化反应,生成1,3-二酯取代的杯[4]芳烃。它还与芳基硼酸在氧化铜(I)共催化下发生Suzuki型交叉偶联反应

应用

溴乙酸乙酯用于在水性介质中制备可逆光敏香豆素稳定的聚合物纳米颗粒,其可用作可检测的药物载体

象形图

FlameSkull and crossbones

警示用语:

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Flam. Liq. 3

储存分类代码

3 - Flammable liquids

WGK

WGK 3

闪点(°F)

116.6 °F - closed cup

闪点(°C)

47 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Unusual pathway of alkylation of 2-(4-bromobenzylidene)-p-menthan-3-one with ethyl bromoacetate
AI Krivoshei, et al.
Russian Chemical Bulletin, 56, 2506-2509 (2007)
Jae Woo Chung et al.
Small (Weinheim an der Bergstrasse, Germany), 8(11), 1693-1700 (2012-03-29)
The ability to create aqueous suspended stable nanoparticles of the hydrophobic homopolymer poly(ϵ-caprolactone) end-functionalized with coumarin moieties (CPCL) is demonstrated. Nanoparticles of CPCL are prepared in a continuous manner using nanoprecipitation. The resulting nanoparticles are spherical in morphology, about 40
Synthesis and cytotoxicity of 28-carboxymethoxy lupane triterpenoids. Preference of 28-O-acylation over 28-O-alkylation of betulin by ethyl bromoacetate
AA Mar, et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 20, 1141-1144 (2009)
Gillian McMahon et al.
Talanta, 57(6), 1119-1132 (2008-10-31)
A series of derivatisation reactions between p-t-butyl calix[4]arene and ethyl bromoacetate were carried out in order to prepare 1,3 diester substituted calix[4]arene. Mass spectral data, obtained from direct injection of samples, indicated that the reactions were rich in the desired
Monika Wujec et al.
The journal of physical chemistry. B, 112(39), 12414-12419 (2008-09-11)
The influence of the implicit solvent model on transition state structures of two S N2 reactions of biochemical importance is presented. In the considered methyl transfer reaction, we show experimentally that the rate constant in blood serum is about 60%

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