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管理合规性
suitable for FDA C-010.02
质量水平
方案
97%
表单
liquid
密度
0.92 g/mL at 25 °C (lit.)
官能团
ketone
储存温度
2-8°C
SMILES字符串
CN1CCC(=O)CC1
InChI
1S/C6H11NO/c1-7-4-2-6(8)3-5-7/h2-5H2,1H3
InChI key
HUUPVABNAQUEJW-UHFFFAOYSA-N
应用
N-甲基-4-哌啶酮可作为反应物，用于制备：
- 螺环哌啶环，通过与丙二腈与亲电试剂或Michael受体反应。
- (3E,5E)-1-甲基-3,5-双(苯亚甲基)-4-哌啶酮，通过Michael加成反应与苯甲醛反应，然后发生O-环化/消除连续反应。
- N,N′-Dimethylbispidinone，使用双曼尼希冷凝法。
Analogs of sparteine. I. Reexamination of the reaction of N-methyl-4-piperidone with formaldehyde and methylamine. Revised synthesis of N, N'-dimethylbispidinone
Smissman EE, et al.
The Journal of Organic Chemistry, 40, 251-252 (1975)
Novel route to spiropiperidines using N-methyl-4-piperidone, malononitrile and electrophiles
Lakshmi NV, et al.
Tetrahedron Letters, 53, 1282-1286 (2012)
Bin-Rong Yao et al.
European journal of medicinal chemistry, 167, 187-199 (2019-02-17)
To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity
A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno [3, 2-c] pyridines
Sumesh RV, et al.
Molecular Diversity, 19, 233-249 (2015)
Analogs of sparteine. I. A reexamination of the reaction of n-methyl-4-piperidone with formaldehyde and methylamine. A revised synthesis of n,n'-dimethylbispidinone.
E E Smissman et al.
The Journal of organic chemistry, 40(2), 251-252 (1975-01-24)
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