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蒸汽压
4.67 psi ( 20 °C)
质量水平
方案
98%
表单
liquid
自燃温度
527 °F
折射率
n20/D 1.420 (lit.)
沸点
49-50 °C (lit.)
密度
0.824 g/mL at 25 °C (lit.)
SMILES字符串
NC1CC1
InChI
1S/C3H7N/c4-3-1-2-3/h3H,1-2,4H2
InChI key
HTJDQJBWANPRPF-UHFFFAOYSA-N
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应用
环丙胺 (CPA) 用于 N -\ [4-（4-氟）苯基-2-氨基噻唑-5-基] 嘧啶-2-基-烷基胺衍生物的合成 。已用于合成 Pt (CPA) 2 （ 双甲硫亚甲基丙二酸酯）和 Pt (CPA) 2 （双 乙基硫亚甲基丙二酸酯）配合物 。
生化/生理作用
环丙胺通过一种机制使细胞色素 P450 酶失活，该机制包括在氮气中先发生单电子氧化，然后环丙烷环断裂，导致酶的共价修饰 。它是 脱氮副球菌 中一种基于机制的喹啉甲胺脱氢酶抑制剂。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1B
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
33.8 °F - closed cup
闪点(°C)
1 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles
法规信息
危险化学品
Synthesis and Antifungal Activity of 5-[2-(Alkylamino) pyrimidin-4-yl]-4-phenylthiazol-2-cycloalkylamine Derivatives on Phytophthora capsici.
Nam Sw, et al.
J. Korean Chem. Soc., 54(3), 395-402 (2011)
Dapeng Sun et al.
FEBS letters, 517(1-3), 172-174 (2002-06-14)
Cyclopropylamine is a mechanism-based inhibitor of the quinoprotein methylamine dehydrogenase (MADH) from Paracoccus denitrificans. The resulting inactivation is accompanied by the formation of a covalent cross-link between the alpha and beta subunits of MADH. The results of site-directed mutagenesis studies
Bram Denolf et al.
Organic letters, 9(2), 187-190 (2007-01-16)
Treatment of novel chiral N-sulfinyl alpha-chloro ketimines with Grignard reagents resulted in the synthesis of chiral N-(1-substituted cyclopropyl)-tert-butanesulfinamides in acceptable to good yields and diastereoselectivity via 1,3-dehydrohalogenation and subsequent addition of the Grignard reagent to the intermediate cyclopropylideneamine. Only in
Grazia Chiellini et al.
Steroids, 77(3), 212-223 (2011-12-03)
Selective inhibitors of CYP24A1 represent an important synthetic target in a search for novel vitamin D compounds of therapeutic value. In the present work, we show the synthesis and biological properties of two novel side chain modified 2-methylene-19-nor-1,25(OH)(2)D(3) analogs, the
Christopher L Shaffer et al.
Journal of the American Chemical Society, 124(28), 8268-8274 (2002-07-11)
The role of single electron transfer (SET) in P450-catalyzed N-dealkylation reactions has been studied using the probe substrates N-cyclopropyl-N-methylaniline (2a) and N-(1'-methylcyclopropyl)-N-methylaniline (2b). In earlier work, we showed that SET oxidation of 2a by horseadish peroxidase leads exclusively to products
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