122564
二氯甲基二乙胺 盐酸盐
98%
别名:
2-氯-N-(2-氯乙基)-N-甲基乙胺, N-甲基双(2-氯乙基)胺 盐酸盐, 二(2-氯乙基)甲基胺, 双(2-氯乙基)甲胺, 氮芥
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关于此项目
线性分子式:
(ClCH2CH2)2NCH3·HCl
化学文摘社编号:
分子量:
192.51
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
200-246-0
MDL number:
Assay:
98%
Form:
solid
InChI key
QZIQJVCYUQZDIR-UHFFFAOYSA-N
InChI
1S/C5H11Cl2N.ClH/c1-8(4-2-6)5-3-7;/h2-5H2,1H3;1H
SMILES string
Cl.CN(CCCl)CCCl
assay
98%
form
solid
mp
108-111 °C (lit.)
solubility
H2O: very soluble, alcohol: soluble
functional group
amine, chloro
Quality Level
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Application
Mechlorethamine hydrochloride was used in a fluorescence-based apurinic/apyrimidinic site cleavage assay for the identification of apurinic/apyrimidinic endonuclease inhibitors in human cells. It was used in a study to demonstrate the effect of povidone iodine ointment against skin toxicity caused by sulphur and nitrogen mustard.
Biochem/physiol Actions
Mechlorethamine hydrochloride administration reduces the tensile strength of the abdominal wounds in rats.
signalword
Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Carc. 1B - Eye Dam. 1 - Muta. 1B - Repr. 1B - Skin Corr. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
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Effect of mechlorethamine hydrochloride (nitrogen mustard) on healing of abdominal wounds.
S M FARHAT et al.
A.M.A. archives of surgery, 76(5), 749-751 (1958-05-01)
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Nucleic acids research, 33(15), 4711-4724 (2005-08-23)
The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP
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