所有图片(1)
About This Item
线性分子式:
HCONHC6H11
CAS号:
分子量:
127.18
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
方案
99%
表单
solid
沸点
113 °C/700 mmHg (lit.)
mp
36-41 °C (lit.)
官能团
amide
SMILES字符串
O=CNC1CCCCC1
InChI
1S/C7H13NO/c9-6-8-7-4-2-1-3-5-7/h6-7H,1-5H2,(H,8,9)
InChI key
SWGXDLRCJNEEGZ-UHFFFAOYSA-N
基因信息
human ... ADH1A(124) , ADH1B(125) , ADH1C(126) , ADH4(127) , ADH7(131) , EPHX2(2053)
mouse ... Ephx2(13850)
一般描述
N-Cyclohexylformamide binds to the complex of horse liver alcohol dehydrogenase with NADH and is similar to the Michaelis complex for aldehyde reduction catalyzed by the enzyme. It is formed during hydration of cyclohexyl isocyanide catalyzed by a novel enzyme isonitrile hydratase from Pseudomonas putida N19-2 .
应用
N-Cyclohexylformamide was used in the synthesis of 2-methylidene-1,3-selenazolidine derivatives.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
>235.4 °F - closed cup
闪点(°C)
> 113 °C - closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Selenium-containing heterocycles from isoselenocyanates: synthesis of 2-methylidene-1, 3-selenazolidine derivatives.
Sommen GL, et al.
Tetrahedron, 62(14), 3344-3354 (2006)
Discovery of a novel enzyme, isonitrile hydratase, involved in nitrogen-carbon triple bond cleavage.
M Goda et al.
The Journal of biological chemistry, 276(26), 23480-23485 (2001-04-18)
Isonitrile containing an N triple bond C triple bond was degraded by microorganism sp. N19-2, which was isolated from soil through a 2-month acclimatization culture in the presence of this compound. The isonitrile-degrading microorganism was identified as Pseudomonas putida. The
H Deng et al.
Biochemistry, 37(40), 14267-14278 (1998-10-07)
The binding of N-cyclohexylformamide (CXF) to the complex of horse liver alcohol dehydrogenase with NADH mimics that of the Michaelis complex for aldehyde reduction catalyzed by the enzyme. The Raman spectra of bound CXF and its 13C- and 15N-substituted derivatives
Uncompetitive inhibitors of alcohol dehydrogenases.
B V Plapp et al.
Advances in experimental medicine and biology, 463, 295-303 (1999-06-03)
S Ramaswamy et al.
Biochemistry, 36(12), 3522-3527 (1997-03-25)
Amides are analogs of aldehydes and potent inhibitors of liver alcohol dehydrogenases. They can be used for structural studies and for inhibiting the metabolism of alcohols that form toxic products. We studied N-alkyl amides that bind to the enzyme-NADH complex
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