119474
N-羟基尿烷
别名:
N-羟基氨基甲酸乙酯
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线性分子式:
HONHCOOCH2CH3
化学文摘社编号:
分子量:
105.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
209-648-0
Beilstein/REAXYS Number:
1747529
MDL number:
InChI key
VGEWEGHHYWGXGG-UHFFFAOYSA-N
InChI
1S/C3H7NO3/c1-2-7-3(5)4-6/h6H,2H2,1H3,(H,4,5)
SMILES string
CCOC(=O)NO
refractive index
n20/D 1.445 (lit.)
bp
113-116 °C/3 mmHg (lit.)
storage temp.
−20°C
Application
N-Hydroxyurethane was used to synthesize N-methyl-O-benzylhydroxylamine and N-isopropyl-O-methylhydroxylamine.
Reactant involved in:
- Synthesis of molecules used for intermolecular Sharpless aminohydroxylation reactions
- Intermolecular ortho-C-H amidation of anilides
- Cinchona alkaloid-catalyzed asymmetric cycloaddition
- Allylic arylation
Biochem/physiol Actions
N-Hydroxyurethane causes the chromosomal fragmentation at millimolar concentrations and cell toxicity in cultured normal human leukocytes.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves
法规信息
新产品
此项目有
P M Weiss et al.
Biochemistry, 23(19), 4346-4350 (1984-09-11)
The true substrate for the pyruvate kinase catalyzed phosphorylation of hydroxylamine at high pH which is activated by bicarbonate is shown to be N-hydroxycarbamate, since a lag is seen when the reaction is started by the addition of bicarbonate or
Kinetic applications of electron paramagnetic resonance spectroscopy. 28. N-Alkoxy-N-alkylamino, N-alkoxyamino, and N-alkoxyanilino radicals.
Kaba RA and Ingold KU
Journal of the American Chemical Society, 98(23), 7375-7380 (1976)
Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine.
T Nomura
Cancer research, 40(4), 1332-1340 (1980-04-01)
S Rossberger et al.
Mutation research, 145(3), 201-207 (1985-05-01)
N-Hydroxyurea and two structurally related compounds, acetohydroxamic acid and N-hydroxyurethane, were investigated for their potential to induce DNA repair synthesis in primary rat hepatocyte cultures. Repair was determined as repair replication by means of the bromodeoxyuridine density-shift method and, in
Katsuhisa Sakano et al.
Free radical biology & medicine, 33(5), 703-714 (2002-09-05)
Carcinogenic urethane (ethyl carbamate) forms DNA adduct via epoxide, whereas carcinogenic methyl carbamate can not. To clarify a mechanism independent of DNA adduct formation, we examined DNA damage induced by N-hydroxyurethane, a urethane metabolite, using 32P-5'-end-labeled DNA fragments. N-hydroxyurethane induced
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