质量水平
检测方案
98%
折射率
n20/D 1.432 (lit.)
bp
78-81 °C/10 mmHg (lit.)
溶解性
THF: soluble
SMILES字符串
CC1CCOC1=O
InChI
1S/C5H8O2/c1-4-2-3-7-5(4)6/h4H,2-3H2,1H3
InChI key
QGLBZNZGBLRJGS-UHFFFAOYSA-N
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一般描述
α-甲基-γ-丁内酯发生苄基化反应生成外消旋α-苄基-α-甲基-γ-丁内酯。
应用
以α-甲基-γ-丁内酯为模型化合物，在交叉实验中研究了毛果芸香碱的热力学优势反应位点。
WGK
WGK 3
闪点(°F)
163.4 °F
闪点(°C)
73 °C
个人防护装备
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
M Satterfield et al.
Journal of the American Society for Mass Spectrometry, 10(3), 209-216 (1999-03-09)
Analysis of the sites of reaction of a biologically important compound, pilocarpine, a molecule with imidazole and butyrolactone rings connected by a methylene bridge, has been accomplished in a quadrupole ion trap with the aim of characterizing its structure/reactivity relationships.
Eric B Gonzales et al.
The Journal of pharmacology and experimental therapeutics, 309(2), 677-683 (2004-01-27)
Alkyl-substituted butyrolactones have both inhibitory and stimulatory effects on GABA(A) receptors. Lactones with small alkyl substitutions at the alpha-position positively modulate the channel, whereas beta-substituted lactones tend to inhibit the GABA(A) receptor. These compounds mediate inhibition through the picrotoxin site
Hagai Tavori et al.
Bioorganic & medicinal chemistry, 16(15), 7504-7509 (2008-06-24)
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the
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