116238
5,7-二甲氧基香豆素
98%
别名:
利美汀, 柠檬油素
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关于此项目
经验公式（希尔记法）:
C11H10O4
化学文摘社编号:
分子量:
206.19
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
207-646-4
MDL number:
Assay:
98%
Form:
solid
InChI key
NXJCRELRQHZBQA-UHFFFAOYSA-N
InChI
1S/C11H10O4/c1-13-7-5-9(14-2)8-3-4-11(12)15-10(8)6-7/h3-6H,1-2H3
SMILES string
COc1cc(OC)c2C=CC(=O)Oc2c1
assay
98%
form
solid
mp
146-149 °C (lit.)
functional group
ester
Quality Level
General description
从茴香 H. Mann 的叶子和果实中分离和鉴定出 5,7-二甲氧基香豆素，该植物的果实用于构建莫霍克花环。它在细菌中诱导移码诱变。它还会在中国仓鼠细胞中引起致命的光敏化和姐妹染色单体交换的形成。
Biochem/physiol Actions
5,7-二甲氧基香豆素诱导小鼠（B16） 和人类（A375） 的分化和黑色素生成过程。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Takeshi Kinoshita et al.
Chemical & pharmaceutical bulletin, 50(1), 118-120 (2002-02-05)
A new C-8 prenylated 5,7-dimethoxycoumarin named omphamurrayin was isolated from the leaves of Murraya paniculata var. omphalocarpa, and its structure was established as 5,7-dimethoxy-8-(1-oxo-2-senecioyl-3-methyl-3-butenyl)-2H-1-benzopyran-2-one on the basis of the spectroscopic evidence. The taxonomic status of M. paniculata var. omphalocarpa is
Daniela Alesiani et al.
International journal of oncology, 34(6), 1727-1735 (2009-05-09)
In this study, the processes of differentiation and melanogenesis induced by 5,7-dimethoxycoumarin in murine (B16) and human (A375) melanoma cells were investigated. Taking into account the previously demonstrated antiproliferative and differentiation activities of this compound, we examined Ras/Raf/Mek/Erk mitogen-activated protein
V Jung et al.
Biochimica et biophysica acta, 740(1), 64-72 (1983-05-20)
The photobinding of 5,7-dimethoxycoumarin to isolated adenovirus-type 2 DNA has been investigated with respect to the influence of the ionic environment, and varying molar ratios of DNA(p): 5,7-dimethoxycoumarin. In particular, the ultraviolet radiation-induced covalent addition of 5,7-dimethoxycoumarin to adenovirus DNA
M J Ashwood-Smith et al.
Experientia, 39(3), 262-264 (1983-03-15)
Some biological properties of 5,7-dimethoxycoumarin (DMC) include dark induced frameshift mutagenesis in bacteria, lethal photosensitization and the formation of sister chromatid exchanges in Chinese hamster cells. The number of sister chromatid exchanges per unit of cell lethality produced by DMC
Isolation and characterization of the photoadducts of 5,7-dimethoxycoumarin and adenosine.
T H Cho et al.
Photochemistry and photobiology, 46(2), 305-309 (1987-08-01)
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