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115312

Sigma-Aldrich

N-ω-甲基色胺

99%

别名:

2-(吲哚-3-基)-N-甲基乙胺, 3-(2-[甲氨基]乙基)吲哚, 3-(2-甲基氨基乙基)吲哚, N-单甲基色胺, N10-甲基色胺, 甲基色胺

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About This Item

经验公式（希尔记法）:
C11H14N2
CAS号:
61-49-4
分子量:
174.24
EC 号:
200-507-9
MDL编号:
MFCD00005657
UNSPSC代码:
12352100
PubChem化学物质编号:
24847209
NACRES:
NA.22

质量水平

200

方案

99%

表单

solid

mp

87-89 °C (lit.)

官能团

amine

SMILES字符串

CNCCc1c[nH]c2ccccc12

InChI

1S/C11H14N2/c1-12-7-6-9-8-13-11-5-3-2-4-10(9)11/h2-5,8,12-13H,6-7H2,1H3

InChI key

NCIKQJBVUNUXLW-UHFFFAOYSA-N

相关类别

应用

N-ω-甲基色胺已用于制备N-乙酰基-α−甲基色胺。
N-ω-甲基色胺已用于通过钩藤(U. tomentosa)蛋白提取物生物合成dolichantoside。
作为反应物用于制备：
  • Manzamine类似物用于控制神经炎症和脑部感染
  • 血清素4受体(5-HT4)受体激动剂
  • Glypetelotine，一种含硫的吲哚生物碱
  • 周期蛋白依赖性激酶(CDK4)的选择性抑制剂
  • 人速激肽NK-2受体拮抗剂
  • 酪氨酸特异性蛋白激酶pp60c-src SH2结构域的抑制剂

包装

无底玻璃瓶。内含物装在锥底内插管中。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK9960
BCCG4027
BCCF9586
BCCF0898
1430965V

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R W Walker et al.
Journal of chromatography, 289, 223-229 (1984-04-27)
A capillary column gas-liquid chromatography selected ion monitoring-based method was developed for the measurement of [13C,15N]N-methyltryptamine ( NMT ) in human urine. The method was employed to establish the extent of conversion of [13C,15N]tryptamine to the correspondingly labeled NMT in
Luigi Servillo et al.
Journal of agricultural and food chemistry, 60(37), 9512-9518 (2012-09-11)
The occurrence of N-methylated tryptamine derivatives in bergamot plant (Citrus bergamia Risso et Poit) is reported for the first time. Interestingly, the most abundant of these substances is N,N,N-trimethyltryptamine, which has not been previously identified in any citrus plant. The
Strictosidine-related enzymes involved in the alkaloid biosynthesis of Uncaria tomentosa root cultures grown under oxidative stress.
Vera-Reyes I, Huerta-Heredia AA, Ponce-Noyola T, et al.
Biotechnology Progress, doi:10-doi:10 (2013)
T J Williams et al.
European journal of pharmacology, 245(3), 197-201 (1993-05-15)
The binding of [3H]5-hydroxytryptamine (5-HT) to rat enteric membranes was inhibited by the inclusion of 5-HT 2-methyl-5-HT, 5-hydroxytryptophan, N,N,N-triethyltryptamine and 2-Br-N,N-diethyltryptamine in the incubation buffer. In contrast, tryptamine, 5-methoxytryptamine and 2-methyl-N,N-diethyltryptamine enhanced binding. Ascorbate and dithiothreitol facilitated and reduced binding
R N Cory et al.
The Journal of pharmacology and experimental therapeutics, 241(1), 258-267 (1987-04-01)
5-Hydroxytryptamine (5-HT) stimulates the accumulation of inositol-trisphosphate in WRK1 cells, a cell line originating from a rat mammary tumor. 5-HT acts via a single receptor type for which it has an affinity constant estimated to be 1.27 microM. A series
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