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Merck
CN
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安全信息

115207

Sigma-Aldrich

羟基脲

98%

别名:

羟基尿素

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About This Item

线性分子式:
NH2CONHOH
CAS号:
127-07-1
分子量:
76.05
Beilstein:
1741548
EC 号:
204-821-7
MDL编号:
MFCD00007943
UNSPSC代码:
12352103

方案

98%

SMILES字符串

NC(=O)NO

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChI key

VSNHCAURESNICA-UHFFFAOYSA-N

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应用

DNA 合成抑制剂。

生化/生理作用

抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。

替代产品

产品编号
说明
价格

H8627

羟基脲, 98%, powder

法规信息

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分析证书(COA)

Lot/Batch Number
21623AA
19430LS
16530TA
15727DZ
15015AO

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N-Hydroxyurea binds both to carbonic anhydrase (CA) and to matrix metalloproteinases (MMPs). X-ray crystallography showed N-hydroxyurea to bind in a bidentate mode by means of the oxygen and nitrogen atoms of the NHOH moiety to the Zn(II) ion of CA
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