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Merck
CN

11373

Sigma-Aldrich

HATU

≥98.0% (CHN), for peptide synthesis

别名:

1-[双(二甲基氨基)亚甲基]-1H-1,2,3-三唑[4,5-b]吡啶-3-氧化物六氟磷酸酯, N-[(二甲基氨基)-1H-1,2,3-三唑-[4,5-b]吡啶-1-亚甲基]-N-甲基甲铵六氟磷酸酯- N-氧化物, HATU

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About This Item

经验公式(希尔记法):
C10H15F6N6OP
分子量:
380.23
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.22

product name

HATU, ≥98.0% (CHN)

质量水平

检测方案

≥98.0% (CHN)

形式

solid

反应适用性

reaction type: Coupling Reactions

mp

183-185 °C (lit.)
183-188 °C (dec.)

应用

peptide synthesis

储存温度

2-8°C

SMILES字符串

F[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12

InChI

1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1

InChI key

FKBFHOSFPRWJNV-UHFFFAOYSA-N

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应用

用作以下反应的试剂:
Aurora A激酶抑制剂的合成
人血浆中的D-和L-酸对映体的HPLC测定
酰胺键形成反应

用作以下反应的催化剂:
选择性酰化反应
硒环化-氧化脱硒连续反应

其他说明

最近研究表明,这种偶联剂的晶体和溶液结构是胍的N-氧化物形式,而不是脲化合物;固相肽合成的优势偶联剂。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Resp. Sens. 1 - Skin Sens. 1A

补充剂危害

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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