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质量水平
检测方案
98%
mp
140-142 °C (lit.)
SMILES字符串
COc1cc(ccc1N)[N+]([O-])=O
InChI
1S/C7H8N2O3/c1-12-7-4-5(9(10)11)2-3-6(7)8/h2-4H,8H2,1H3
InChI key
GVBHRNIWBGTNQA-UHFFFAOYSA-N
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一般描述
2-甲氧基-4-硝基苯胺由于分子量小，因此是 CYP1A2 的重要诱导剂。
应用
2-甲氧基-4-硝基苯胺作为光度试剂，用于测定乙炔雌醇（ETE），乙炔雌醇是一种半合成的雌激素，广泛用于口服避孕药。
生化/生理作用
在 Harlan Sprague Dawley 大鼠和 B6C3F（1）/N 小鼠中，2-甲氧基-4-硝基苯胺（MNA）通过苯环的羟基化作用代谢生成 6-羟基 MNA。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
危险化学品
James M Mathews et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(12), 1213-1224 (2012-06-26)
The disposition of 2-Methoxy-4-nitroaniline (MNA) was investigated in male and female Harlan Sprague Dawley rats and B6C3F(1)/N mice following oral, intravenous, and dermal exposure to [(14)C]MNA at 2, 15, or 150 mg/kg. Clearance of MNA was investigated in male and
M Degawa et al.
Cancer letters, 96(1), 95-98 (1995-09-04)
Male F344 rats were treated with a chemical (aniline, nitrobenzene, 2-methoxy-p-phenylenediamine, 2-methoxy-4-nitroaniline or 2-methoxy-4-nitroazobenzene) produced by the azo-reduction and/or N-oxidation of 2-methoxy-4-amino-azo-benzene, a selective inducer of cytochrome P450IA2 (CYP1A2), and their effects on the induction of CYP1A enzymes in the
Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations.
Leonardo SG, et al.
Analytical Methods : Advancing Methods and Applications, 3(5), 1198-1201 (2011)
Rachel P Frawley et al.
Toxicology, 441, 152474-152474 (2020-05-08)
2-Methoxy-4-nitroaniline (MNA), an intermediate in the synthesis of azo dyes used in textiles and paints, is structurally similar to carcinogenic anilines. Human exposure occurs primarily in the occupational setting through handling of dye dust, and through use and disposal of
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