112194
六氯-1,3-丁二烯
96%
别名:
全氯丁二烯
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关于此项目
线性分子式:
CCl2=CClCCl=CCl2
化学文摘社编号:
分子量:
260.76
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-765-5
Beilstein/REAXYS Number:
1766570
MDL number:
Assay:
96%
Form:
liquid
InChI key
RWNKSTSCBHKHTB-UHFFFAOYSA-N
InChI
1S/C4Cl6/c5-1(3(7)8)2(6)4(9)10
SMILES string
Cl\C(Cl)=C(Cl)/C(Cl)=C(\Cl)Cl
vapor pressure
0.2 mmHg ( 20 °C)
assay
96%
form
liquid
Quality Level
refractive index
n20/D 1.555 (lit.)
bp
210-220 °C (lit.)
mp
−22-−19 °C (lit.)
density
1.665 g/mL at 25 °C (lit.)
functional group
chloro
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Application
六氯-1,3-丁二烯用于研究茴香脑二硫基硫酮（ADT）对六氯-1,3-丁二烯（HCBD）诱导的大鼠肾毒性的影响。
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
有毒化学品
此项目有
L Bouthillier et al.
Toxicology and applied pharmacology, 139(1), 177-185 (1996-07-01)
Administration of anethol dithiolthione (ADT) to rodents can afford protection against some chemically induced toxicities. The aim of the present study was to assess the effects of ADT on hexachloro-1,3-butadiene (HCBD)-induced nephrotoxicity in the rat and to determine the mechanism
Arianna Chiusolo et al.
Toxicology letters, 182(1-3), 84-90 (2008-09-23)
Gene expression of regucalcin (Rgn), a calcium-binding protein, was investigated in kidney of male Wistar rats treated with proximal tubule segment-specific nephrotoxicants, namely hexachloro-1:3-butadiene (HCBD), specific for S(3) segment (pars recta) and potassium dichromate (chromate) specific for S(1)-S(2) segments (pars
Hexachloro-1,3-butadiene: toxicology, metabolism, and mechanisms of toxicity.
R S Yang
Reviews of environmental contamination and toxicology, 101, 121-137 (1988-01-01)
Aubrey Swain et al.
Journal of applied toxicology : JAT, 32(6), 417-428 (2011-09-10)
Hexachloro-1:3-butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5-90 mg kg⁻¹ to determine the
Renal proximal tubule segment-specific nephrotoxicity: an overview on biomarkers and histopathology.
Patrizia Cristofori et al.
Toxicologic pathology, 35(2), 270-275 (2007-03-17)
The correspondence between histopathological findings and segment-specific biomarkers was investigated in rats treated with segment-specific nephrotoxicants. Male Wistar rats were treated with a single injection of K2Cr2O7 (25 mg/kg s.c. in saline), cis-Pt (10 mg/kg i.p. in buffered MSO) or
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