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Merck
CN

108448

Sigma-Aldrich

氰基乙酰胺

99%

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别名:
2-Cyanoacetamide
线性分子式:
NCCH2CONH2
CAS号:
分子量:
84.08
Beilstein:
878221
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

质量水平

检测方案

99%

mp

119-121 °C (lit.)

溶解性

cold water: soluble 1gm in 6.5ml

SMILES字符串

NC(=O)CC#N

InChI

1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)

InChI key

DGJMPUGMZIKDRO-UHFFFAOYSA-N

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一般描述

氰乙酰胺是合成维生素B6的起始试剂。它与硼酸缓冲液中的还原性碳水化合物反应,产生强烈的荧光,可用于碳水化合物作为硼酸盐络合物的自动分析

氰乙酰胺是一种高度反应性化合物,常用作缩合和取代反应中的反应中间体。

应用

氰基乙酰胺可用于荧光分光光度法对一些抗组胺H1受体拮抗剂药物进行测定,例如依巴斯汀、二盐酸西替利嗪、以及盐酸非索非那定。它可用于3,4-二羟基苯丙氨酸的荧光测定。它可用作兔血清中壳聚糖酯的生物分析和药代动力学的柱后荧光衍生剂。

象形图

Exclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 2

闪点(°F)

419.0 °F

闪点(°C)

215 °C

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Cyanoacetamide derivatives as synthons in heterocyclic synthesis
Fadda, et al.
Turkish Journal of Chemistry, 32, 259-286 (2008)
Cyanoacetamide derivatives as synthons in heterocyclic synthesis.
Fadda AA, et al.
Turkish Journal of Chemistry, 32(3), 259-286 (2008)
Gregg A Duncan et al.
Molecular therapy. Methods & clinical development, 9, 296-304 (2018-07-25)
Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we
Xiaofei Zeng et al.
Organic letters, 12(10), 2414-2417 (2010-05-01)
A clean and highly efficient enantioselective addition of alpha-isocyanoacetamides to aliphatic aldehydes catalyzed by chiral phosphoric acid in the presence of MS 5 A in toluene at -40 degrees C was developed. Excellent yields (85-98%) and good to excellent enantioselectivities
Kan Wang et al.
Journal of combinatorial chemistry, 11(5), 920-927 (2009-08-22)
Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. However the diversity of these scaffolds is hampered by the low variability of the cyanoacetic acid derivatives in the past. Here we describe valuable protocols

商品

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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