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Merck
CN

108421

Sigma-Aldrich

氰基乙酸甲酯

99%

别名:

Methyl 2-cyanoacetate

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About This Item

线性分子式:
NCCH2COOCH3
CAS号:
分子量:
99.09
Beilstein:
773945
EC 号:
MDL编号:
UNSPSC代码:
12352100
eCl@ss:
39031513
PubChem化学物质编号:
NACRES:
NA.22

蒸汽密度

3.41 (vs air)

质量水平

蒸汽压

0.2 mmHg ( 20 °C)

检测方案

99%

折射率

n20/D 1.417 (lit.)

bp

204-207 °C (lit.)

mp

−13 °C (lit.)

密度

1.123 g/mL at 25 °C (lit.)

SMILES字符串

COC(=O)CC#N

InChI

1S/C4H5NO2/c1-7-4(6)2-3-5/h2H2,1H3

InChI key

ANGDWNBGPBMQHW-UHFFFAOYSA-N

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一般描述

氰基乙酸甲酯是药物有机合成以及合成农业中使用的一些生物活性化合物的中间产物 。它与芳香醛发生方解石或萤石催化的 Knövenagel 缩合反应,得到相应的的芳亚芳基马来腈和 ( E )-α-氰酸酯

应用

氰乙酸甲酯可用于合成各种 1,2,5-三羰基化合物

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

WGK

WGK 1

个人防护装备

Eyeshields, Gloves


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Conformational isomerism in methyl cyanoacetate: A combined matrix-isolation infrared spectroscopy and molecular orbital study.
Reva ID, et al
Physical Chemistry Chemical Physics, 3(19), 4235-4241 (2011)
Construction of 1, 2, 5-Tricarbonyl Compounds using Methyl Cyanoacetate as a Glyoxylate Anion Synthon Combined with Copper (I) Iodide-Catalyzed Aerobic Oxidation.
Kim SH, et al.
Advanced Synthesis & Catalysis, 353(18), 3335-3339 (2011)
Calcite and fluorite as catalyst for the Knovenagel condensation of malononitrile and methyl cyanoacetate under solvent-free conditions.
Wada S and Suzuki H.
Tetrahedron Letters, 44(2), 399-401 (2003)
Søren S Donau et al.
Chemosphere, 233, 873-878 (2019-07-26)
The cyanoacrylate ethyl (2Z)-3-amino-2-cyano-3-phenylacrylate (phenamacril), has been introduced as an effective agent against several fungi species belonging to the Fusarium genus. However, in current literature, knowledge about the environmental behavior of this fungicide is limited and there are no data
Yulia Kaluzhny et al.
Alternatives to laboratory animals : ATLA, 43(2), 101-127 (2015-05-23)
The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other

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