推荐产品
产品名称
五氟苯酚, ReagentPlus®, ≥99%
质量水平
产品线
ReagentPlus®
方案
≥99%
表单
solid
沸点
143 °C (lit.)
mp
34-36 °C (lit.)
应用
peptide synthesis
官能团
fluoro
SMILES字符串
Oc1c(F)c(F)c(F)c(F)c1F
InChI
1S/C6HF5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12H
InChI key
XBNGYFFABRKICK-UHFFFAOYSA-N
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一般描述
五氟苯酚被广泛用作溶液和固相肽合成的前体。 它也参与制备芳香族氟衍生物。.
应用
五氟苯酚可作为反应物与以下物质反应合成五氟苯基酯：
- 在二环己基碳二亚胺和乙酸乙酯存在的情况下与N-保护氨基酸反应。在1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐存在的情况下与
- 叔-丁氧羰基-L-丙氨酰甘氨酸反应。
- 在吡啶、二异丙基碳二亚胺和乙腈存在的情况下与脂肪族二羧酸反应。
法律信息
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
161.6 °F - closed cup
闪点(°C)
72 °C - closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Pentafluorophenol
Jones K
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Synthesis and Solid-state Conformations of 6S, 8aR/S-6-Alkyl-3, 3-dimethyltetrahydrooxazolo [3, 4-a] pyrazine-5, 8-diones (Pseudoproline Diketopiperazines)
Beauchard A, et al.
Indian Journal of Heterocyclic Chemistry, 28, 11-24 (2018)
Yutang Dai et al.
Macromolecular rapid communications, 35(15), 1326-1331 (2014-05-28)
Self-assembly of C3 discotic molecules bearing dipeptide pendants into helical supramolecular polymers is investigated. The dipeptides are constituted from glycine and alanine with altered sequence, aiming at modulating the steric hindrance and examining the steric effects on the assembly. This
Rens J Götz et al.
Chemical communications (Cambridge, England), (29)(29), 3384-3386 (2008-07-18)
The rational design of a ligand containing two electron-poor pi-rings, i.e. a triazine and a pentafluorophenoxy groups, has allowed the preparation of a copper complex where both the anticipated anion...pi interactions are present.
M Adamczyk et al.
Bioconjugate chemistry, 8(2), 253-255 (1997-03-01)
A mixture of 5- and 6-carboxyfluorescein was activated with 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride in the presence of either N-hydroxysuccinimide or pentafluorophenol to give the corresponding succinimidyl and pentafluorophenyl esters. The regioisomeric mixtures were separated to give the 5- and 6-succinimidyl and pentafluorophenyl
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