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Merck
CN

NR1H4

nuclear receptor subfamily 1, group H, member 4

别名:
BAR, FXR, HRR-1, HRR1, RIP14
物种:
Human NR1H4 (9971), Mouse Nr1h4 (20186), Rat Nr1h4 (60351), domestic cat NR1H4 (101096997), naked mole-rat Nr1h4 (101714263), cow NR1H4 (540528), domestic guinea pig Nr1h4 (100734377), Zebrafish nr1h4 (436847), Horse NR1H4 (100052821), chicken NR1H4 (373902) ...展开
UniProtKB ID:
Q96RI1, A1L4K5, B7Z412, B7ZM06, F8VYG8, Q8NFP5, Q8NFP6, Q92943
基因ID:
  • Human(9971) Summary: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
  • Mouse(20186) nuclear receptor subfamily 1, group H, member 4
  • Rat(60351) nuclear receptor subfamily 1, group H, member 4
  • domestic cat(101096997) nuclear receptor subfamily 1, group H, member 4
  • naked mole-rat(101714263) nuclear receptor subfamily 1, group H, member 4
  • cow(540528) nuclear receptor subfamily 1, group H, member 4
  • domestic guinea pig(100734377) nuclear receptor subfamily 1, group H, member 4
  • Zebrafish(436847) nuclear receptor subfamily 1, group H, member 4
  • Horse(100052821) nuclear receptor subfamily 1, group H, member 4
  • chicken(373902) nuclear receptor subfamily 1, group H, member 4
  • dog(612928) nuclear receptor subfamily 1, group H, member 4
  • sheep(101105401) nuclear receptor subfamily 1, group H, member 4
  • Domestic Rabbit(100009485) nuclear receptor subfamily 1, group H, member 4

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Small Molecule - Agonist

货号
说明
物种
U5127
熊去氧胆酸, ≥99%,
物种
human
1707806
熊去氧胆酸, United States Pharmacopeia (USP) Reference Standard,
物种
human
BP926
鹅去氧胆酸, British Pharmacopoeia (BP) Reference Standard,
物种
human
PHR1579
熊去氧胆酸, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
C1050000
鹅去氧胆酸, European Pharmacopoeia (EP) Reference Standard,
物种
human

Antibodies

货号
说明
物种反应性
应用
AV33672
抗NR1H4 兔抗, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rat
应用
immunohistochemistry
western blot
WH0009971M1
Monoclonal Anti-NR1H4 antibody produced in mouse, clone 1G11, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunofluorescence
western blot
AB10305
Anti-FXR-B Antibody, serum, Chemicon®,
物种反应性
human
应用
western blot
SAB1404768
Monoclonal Anti-NR1H4, (C-terminal) antibody produced in mouse, clone 1B10, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunofluorescence
western blot
SAB2500384
Anti-Farnesoid X Receptor/HRR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
canine, human
应用
ELISA
western blot

esiRNA

货号
说明
物种
EMU026301
MISSION® esiRNA, targeting mouse Nr1h4,
物种
mouse
EHU133161
MISSION® esiRNA, targeting human NR1H4,
物种
human