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N5266

Sigma-Aldrich

Neurotensin Fragment 8-13 acetate salt

≥97% (HPLC), suitable for ligand binding assays

Synonym(s):

L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

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About This Item

Empirical Formula (Hill Notation):
C38H64N12O8
CAS Number:
60482-95-3
Molecular Weight:
816.99
MDL number:
MFCD00076686
UNSPSC Code:
12352209
PubChem Substance ID:
24897727
NACRES:
NA.26

Product Name

Neurotensin Fragment 8-13 acetate salt, ≥97% (HPLC)

Quality Level

200

Assay

≥97% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C38H64N12O8/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45)

InChI key

DQDBCHHEIKQPJD-UHFFFAOYSA-N

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Amino Acid Sequence

Arg-Arg-Pro-Tyr-Ile-Leu

Biochem/physiol Actions

Neurotensin Fragment 8-13 acetate salt is the smallest active fragment of neurotensin.

Linkage

Smallest active fragment of neurotensin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000351531
0000351528
0000351529
0000351530
0000338657

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Veronique Maes et al.
Journal of medicinal chemistry, 49(5), 1833-1836 (2006-03-03)
Two new 99mTc-labeled neurotensin(8-13) analogues containing the retro-N(alpha)-carboxymethyl-histidine ((N(alpha)His)Ac) chelator were synthesized as potential radiopharmaceuticals for visualization of pancreatic carcinoma. To improve the pharmacokinetic properties, (N(alpha)His)Ac-Arg-NMeArg-Pro-Tyr-Tle-Leu (NT-XII), which is metabolically stabilized at two positions, was further modified. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic
Shifei Xia et al.
Electrophoresis, 28(18), 3268-3276 (2007-09-15)
A new method for the determination of the peptide hormones of brain and intestine based on CE coupling with a DAD and ESI-MS was established. Several electrophoretic and ESI-MS parameters were investigated in detail, such as electrolyte nature and concentration
Kyle P Kokko et al.
Journal of medicinal chemistry, 46(19), 4141-4148 (2003-09-05)
A set of neurotensin[8-13] (NT[8-13]) analogues featuring substitution of non-natural cationic amino acids in the Arg(8) position have been synthesized and tested for binding potencies against the three cloned human NT receptors (hNTR-1, hNTR-2, hNTR-3), functional agonism of the hNTR1
Rodrigo Teodoro et al.
Nuclear medicine and biology, 38(1), 113-120 (2011-01-12)
Several strategies on the development of radiopharmaceuticals have been employed. Bifunctional chelators seem to be a promising approach since high radiochemical yields as well as good in vitro and in vivo stability have been achieved. To date, neurotensin analogs have
Talia Levitas-Djerbi et al.
Neuroendocrinology, 110(1-2), 35-49 (2019-04-29)
Hypothalamic neurotensin (Nts)-secreting neurons regulate fundamental physiological processes including metabolism and feeding. However, the role of Nts in modulation of locomotor activity, sleep, and arousal is unclear. We previously identified and characterized Nts neurons in the zebrafish hypothalamus. In order
View All Related Papers

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