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A9525

Sigma-Aldrich

Angiotensin II human

≥93% (HPLC), powder

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Synonym(s):
1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII
Empirical Formula (Hill Notation):
C50H71N13O12
CAS Number:
4474-91-3
Molecular Weight:
1046.18
UNSPSC Code:
12352202
eCl@ss:
42020611
PubChem Substance ID:
24891466
NACRES:
NA.32

biological source

synthetic

Quality Level

300

Assay

≥93% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

cell culture | mammalian: suitable

impurities

1.2-10.4% acetate

solubility

water: 25 mg/mL, clear, colorless

UniProt accession no.

P01019

storage temp.

−20°C

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... AGT(183)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

General description

Research area: Cell Signaling

Application

  • Angiotensin II (angII) human has been used:
  • to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
  • to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
  • to study the actions of systemic angII infusions on glomerular permeability in vivo.
  • to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.
  • to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.
  • to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

Biochem/physiol Actions

Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.

Features and Benefits

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

Analysis Note

Peptide content not less than 75%

antibody

Product No.
Description
Pricing

HPA001557

Anti-AGT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

SAB2100072

Anti-AGT antibody produced in rabbit, affinity isolated antibody

SAB1405438

Anti-AGT antibody produced in mouse, purified immunoglobulin, buffered aqueous solution

SAB1403532

Monoclonal Anti-AGT antibody produced in mouse, clone 3C10, purified immunoglobulin, buffered aqueous solution

MAB4051

Anti-Angiotensin Converting Enzyme Antibody, clone 9B9, clone 9B9, Chemicon®, from mouse

ZRB1021

Anti-Angiotensinogen Antibody, clone 1B12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

SAB5700748

Anti-AGT antibody produced in rabbit

related product

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Description
Pricing

A9650

Angiotensin I human acetate salt hydrate, ≥90% (HPLC), powder, suitable for mammalian cell culture

A9525

Angiotensin II human, ≥93% (HPLC), powder

A9202

Angiotensin Fragment 1-7 acetate salt hydrate, ≥90% (HPLC), powder

A2562

Angiotensinogen from human plasma, ≥80% (SDS-PAGE), lyophilized powder

EHU131721

MISSION® esiRNA, targeting human AGT

RAB0010

Angiotensin II EIA Kit, for serum, plasma, culture supernatant and cell lysates

92210

Timestrip Plus™ 0 °C

APREST84496

PrEST Antigen AGT, Prestige Antigens™ Powered by Atlas Antibodies, buffered aqueous solution

RAB1021

Human Angiotensinogen ELISA Kit, for cell culture supernatants, plasma, and serum samples

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B Erdmann et al.
Hypertension (Dallas, Tex. : 1979), 28(5), 818-824 (1996-11-01)
We localized angiotensin II (Ang II) immunoreactivity in the rat cerebellar cortex with immunogold staining methods. Perfusion fixation with high amounts of glutaraldehyde and the use of cryoultramicrotomy caused remarkable changes in immunostaining versus formaldehyde/picric acid fixation. With the use
Li-Ming Yu et al.
Free radical biology & medicine, 178, 202-214 (2021-12-06)
Mitochondrial reactive oxygen species (ROS) damage and atrial remodeling serve as the crucial substrates for the genesis of atrial fibrillation (AF). Branched-chain amino acids (BCAAs) catabolic defect plays critical roles in multiple cardiovascular diseases. However, the alteration of atrial BCAA
M R Weir et al.
American journal of hypertension, 12(12 Pt 3), 205S-213S (2000-01-05)
Angiotensin II plays a central role in the regulation of systemic arterial pressure through its systemic synthesis via the renin-angiotensin-aldosterone cascade. It acts directly on vascular smooth muscle as a potent vasoconstrictor. In addition, it affects cardiac contractility and heart
Takumi Ota et al.
Molecular and cellular biology, 34(20), 3880-3894 (2014-08-06)
The 3β-hydroxysteroid dehydrogenase (3β-HSD) is an enzyme crucial for steroid synthesis. Two different 3β-HSD isoforms exist in humans. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform, HSD3B1, is expressed
Xiang He et al.
Theranostics, 9(19), 5558-5576 (2019-09-20)
Objective: Long noncoding RNAs (lncRNAs) may serve as specific targets for the treatment of abdominal aortic aneurysms (AAAs). LncRNA GAS5, functionally associated with smooth muscle cell (SMC) apoptosis and proliferation, is likely involved in AAA formation, but the exact role
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