Skip to Content
Merck
CN

A9650

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

Synonym(s):

5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C62H89N17O14 · xC2H4O2 · yH2O
CAS Number:
70937-97-2
Molecular Weight:
1296.48 (anhydrous free base basis)
UNSPSC Code:
12352202
eCl@ss:
42020611
PubChem Substance ID:
24891483
NACRES:
NA.32
MDL number:
MFCD00133091

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Angiotensin I human acetate salt hydrate, ≥90% (HPLC), powder, suitable for mammalian cell culture

SMILES string

CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1

InChI key

CKIFOTYDIFUKEP-AUVUXLIHSA-N

biological source

human

assay

≥90% (HPLC)

form

powder

mol wt

1296 Da by calculation (Average Mass)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

cell culture | mammalian: suitable

solubility

acetic acid: 25 mg/mL, clear, colorless

UniProt accession no.

P01019

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AGT(183)

Looking for similar products? Visit Product Comparison Guide

Application

Angiotensin I human acetate salt hydrate has been used:
  • as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
  • to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
  • as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

Biochem/physiol Actions

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.
Putative neurotransmitter; precursor of angiotensin II and of angiotensin fragment 1-7.

General description

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Research area: Cell Signaling
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH3COOH.6H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000512780
0000512780
0000492067
0000492067
0000463819

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Toward Systeme International d?Unite-traceable protein quantification: from amino acids to proteins
Burkitt W I, et al.
Analytical biochemistry, 376(2), 242-251 (2008)
R A Santos et al.
Regulatory peptides, 91(1-3), 45-62 (2000-09-01)
The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis
Genetics of Blood Pressure Regulation
Emery and Rimoin's Principles and Practice of Medical Genetics, 1-22 (2013)
Physiology, Renin Angiotensin System
Fountain J H. and Lappin S L.
StatPearls [Internet] (2022)
Protein expression following heat shock in the nervous system of Locusta migratoria
Dehghani M, et al.
Journal of Insect Physiology, 57(11), 1480-1488 (2011)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service