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Key Documents

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Safety Information

A9650

Sigma-Aldrich

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

Synonym(s):

5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I

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50 G
¥963.92
250 G
¥3,219.03

¥963.92

Available to ship on2025年4月23日Details

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50 G
¥963.92
250 G
¥3,219.03

About This Item

Empirical Formula (Hill Notation):
C62H89N17O14 · xC2H4O2 · yH2O
CAS Number:
70937-97-2
Molecular Weight:
1296.48 (anhydrous free base basis)
MDL number:
MFCD00133091
UNSPSC Code:
12352202
eCl@ss:
42020611
PubChem Substance ID:
24891483
NACRES:
NA.32

¥963.92

Available to ship on2025年4月23日Details

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biological source

human

Quality Level

200

Assay

≥90% (HPLC)

form

powder

mol wt

1296 Da by calculation (Average Mass)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

cell culture | mammalian: suitable

solubility

acetic acid: 25 mg/mL, clear, colorless

UniProt accession no.

P01019

storage temp.

−20°C

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磷酸钾二元 二元 suitable for HPLC, LiChropur™, 99.0-101.0% (T)

59678

磷酸钾二元 二元

磷酸钾二元 二元 Vetec™, reagent grade, 98%

V900050

磷酸钾二元 二元

磷酸钾二元 二元 Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS

PX1570

磷酸钾二元 二元

磷酸钾二元 二元 reagent grade, ≥98.0%

P8281

磷酸钾二元 二元

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

technique(s)

-

form

powder or crystals

form

-

form

granular

form

powder

pH

8.7-9.3

pH

-

pH

9 (20 °C, 10 g/L in H2O)

pH

8.7-9.3 (25 °C, 50 g/L)

solubility

H2O: 5%, clear, colorless

solubility

-

solubility

1600 g/L

solubility

water: 200 mg/mL, clear to slightly hazy, colorless

quality

LiChropur™

quality

-

quality

-

quality

-

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

General description

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.[1]

Research area: Cell Signaling

Application

Angiotensin I human acetate salt hydrate has been used:
  • as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix[2],
  • to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis[3]
  • as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry[4]

Biochem/physiol Actions

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system[5] aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.[6]
Putative neurotransmitter; precursor of angiotensin II and of angiotensin fragment 1-7.

Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH3COOH.6H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000417457
    0000417983
    0000417986
    0000417986
    0000417983

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Physiology, Renin Angiotensin System
    Fountain J H. and Lappin S L.
    StatPearls [Internet] (2022)
    Genetics of Blood Pressure Regulation
    Emery and Rimoin's Principles and Practice of Medical Genetics, 1-22 (2013)
    R A Santos et al.
    Regulatory peptides, 91(1-3), 45-62 (2000-09-01)
    The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis
    Toward Systeme International d?Unite-traceable protein quantification: from amino acids to proteins
    Burkitt W I, et al.
    Analytical biochemistry, 376(2), 242-251 (2008)
    Protein expression following heat shock in the nervous system of Locusta migratoria
    Dehghani M, et al.
    Journal of Insect Physiology, 57(11), 1480-1488 (2011)
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