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Merck
CN

05-23-0101

Angiotensin II, Human

Plays an important role in the regulation of blood pressure.

Synonym(s):

Angiotensin II, Human, DRVYIHPF, ang II

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About This Item

Empirical Formula (Hill Notation):
C50H71N13O12
CAS Number:
4474-91-3
Molecular Weight:
1046.18
UNSPSC Code:
12352202
NACRES:
NA.77

Key Documents

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Product Name

Angiotensin II, Human, Plays an important role in the regulation of blood pressure.

SMILES string

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

biological source

human

sterility

non-sterile

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

technique(s)

cell based assay: suitable

color

white to off-white

solubility

5% acetic acid: 1 mg/mL
water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

human ... ACE2(59272)

Related Categories

Application

Angiotensin II, Human has been used to induce fibrosis in mice to evaluate the impact of fibroblast loss on cardiac function after injury. It has also been used to induce abdominal aortic aneurysm (AAA) progression in mice.

Biochem/physiol Actions

Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Furthermore, Angiotensin II stimulates the release of aldosterone from the adrenal gland, contributing to the maintenance of fluid and electrolyte balance regulation. Angiotensin II also promotes inflammation and tissue injury. It Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II also activates JAK2 in smooth muscle cells, as well as several kinases including p125FAK, cytosolic calcium-dependent tyrosine kinase, and p60c-src in various cell types. In vascular smooth muscle cells, it activates ERK1/2, JNK, and p38 MAP Kinase.

Disclaimer

Toxicity: Standard Handling (A)

General description

Research area: Cell signaling

Cell permeable: no

Primary Target adenylate cyclase activity

Product does not compete with ATP.

Reversible: no

Other Notes

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Zhu, M., et al. 2000. J. Neurophysiol.84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

Packaging

Yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Certificates of Analysis (COA)

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Angiotensin II inhibits glomerular adenylate cyclase via the angiotensin II receptor subtype 1 (AT1)
Edwards RM, et al.
Journal of Separation Science, 266(2), 506-510 (1993)
Angiotensin II revisited: new roles in inflammation, immunology and aging
Benigni A, et al.
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Angiotensin II revisited: new roles in inflammation, immunology and aging
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