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Key Documents

Safety Information

F9765

Sigma-Aldrich

Filipin complex

powder, ≥70% (UV)

Synonym(s):

Filimarisin

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25 MG
CN¥471.88
100 MG
CN¥1,135.57
250 MG
CN¥1,869.95
1 G
CN¥5,397.64

CN¥471.88

Estimated to ship onMay 15, 2025Details

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25 MG
CN¥471.88
100 MG
CN¥1,135.57
250 MG
CN¥1,869.95
1 G
CN¥5,397.64

About This Item

CAS Number:
11078-21-0
MDL number:
MFCD00131073
UNSPSC Code:
12352202
NACRES:
NA.77

CN¥471.88

Estimated to ship onMay 15, 2025Details

Request a Bulk Order

Product Name

Filipin complex from Streptomyces filipinensis, ≥70% (UV)

biological source

Streptomyces sp. (Streptomyces filipinensis)

Quality Level

200

Assay

≥70% (UV)

form

powder

solubility

methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow

antibiotic activity spectrum

fungi

Mode of action

cell membrane | interferes

storage temp.

−20°C

InChI

1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1

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Nedaplatin

Carboplatin

C2538

Carboplatin

form

crystalline

form

solid

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

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Quality Level

100

color

yellow

color

yellow

color

-

color

-

originator

Corden

originator

-

originator

-

originator

Bristol-Myers Squibb

mp

270 °C (lit.)

mp

-

mp

-

mp

-

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

neoplastics

General description

Chemical structure: macrolide

Application

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.[1][2][3]

Biochem/physiol Actions

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols. Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Other Notes

Filipin contains 8 isomeric components, with filipin III as the major component.

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000419108
    0000419108
    0000369074
    0000369404
    0000369405

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    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. How should Product F9765, Filipin complex from Streptomyces filipinensis, be solubilized?

      This product has low solubility in aqueous buffers. It should initially be reconstituted in DMSO at 1 mg/mL and then diluted into saline or an aqueous buffer of choice.

    4. What is the stability of stock solutions Product F9765, Filipin complex from Streptomyces filipinensis?

      Solutions of filipin in aqueous or organic solvents are not considered to be stable and it is recommended that they be prepared fresh and not stored as stock solutions.

    5. What is the difference between Filipin products F9765 and F4767?

      The product F9765 consists of a filipin complex. It is composed of 8 isomeric components, of which filipin III is the major component in the complex. F4767 consists of filipin III alone and is considered to be a better choice for staining.

    6. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    7. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    8. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    Yvonne Baumer et al.
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    Nada Kraševec et al.
    Microorganisms, 8(12) (2020-12-17)
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    Glenda M Halliday et al.
    Brain : a journal of neurology, 128(Pt 11), 2654-2664 (2005-07-08)
    The distribution and tempo of neuronal loss in Parkinson's disease correlates poorly with the characteristic and more widely spread intracellular changes associated with the disease process (Lewy bodies and Lewy neurites). To determine early intracellular changes in regions where cell
    Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone (Dp44mT)
    Gutierrez EM,et al.
    Biochimica et Biophysica Acta - Molecular Cell Research, 1863(7), 1665-1681 (2016)
    Analytical characterization of methyl-beta-cyclodextrin for pharmacological activity to reduce lysosomal cholesterol accumulation in Niemann-Pick disease type C1 cells
    Li R, et al.
    Assay and Drug Development Technologies, 15(4), 154-166 (2017)
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