SML2514
Nedaplatin
Synonym(s):
Nedaplatin, Cis-Diammine (Glycolato)Platinum
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About This Item
Empirical Formula (Hill Notation):
C2H8N2O3Pt
CAS Number:
Molecular Weight:
303.17
UNSPSC Code:
12352200
NACRES:
NA.77
form
powder
storage temp.
2-8°C
SMILES string
[Pt+2].[N-H2].[N-H2].OCC(=O)O
InChI
1S/C2H4O3.2H2N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H2;/q;2*-1;+2
InChI key
KLNFSAOEKUDMFA-UHFFFAOYSA-N
Biochem/physiol Actions
Nedaplatin is a second-generation cisplatin analog with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. Nedplatin is less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1B - Skin Irrit. 2 - Skin Sens. 1B - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Jun Fu et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 25(4), 1707-1713 (2020-10-26)
To investigate the efficacy and safety of irinotecan combined with nedaplatin in the treatment of small cell lung cancer (SCLC). 64 patients diagnosed with SCLC in our hospital from April 2013 to June 2015 were retrospectively analyzed. Thirty-two patients in
Hongmei Zhang et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 25(1), 80-86 (2020-04-12)
To study the efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients. A total of 100 ovarian cancer patients treated in our hospital from January 2015 to
Takuma Kagami et al.
BMC cancer, 20(1), 1123-1123 (2020-11-22)
Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this study, we examined the prognostic value of SLFN11 expression in esophageal squamous cell carcinoma
Tomonori Sasahira et al.
International journal of molecular sciences, 21(10) (2020-05-28)
Because oral squamous cell carcinomas (OSCCs) have a high potential for locoregional invasion and nodal metastasis, early detection and treatment are essential. A LAP2, emerin, MAN1 (LEM) domain containing 1 (LEMD1) is associated with local progression, clinical stage, nodal metastasis
Haruka Miyata et al.
Japanese journal of clinical oncology, 50(5), 609-616 (2020-01-20)
Bladder-preserving trimodal therapy is recognized as a promising alternative treatment for muscle-invasive bladder cancer. We report the updated outcomes of muscle-invasive bladder cancer patients that were treated using our treatment protocol, which involves radiotherapy delivered with a real-time tumor-tracking radiotherapy
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