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form
crystalline
Quality Level
color
yellow
mp
270 °C (lit.)
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
originator
Corden
SMILES string
N.N.Cl[Pt]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI key
LXZZYRPGZAFOLE-UHFFFAOYSA-L
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Application
- in cell viability measurement in cochlear explants
- in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
- in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma
Biochem/physiol Actions
Features and Benefits
Storage and Stability
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the toxicity of Cisplatin, Product P4394?
This information can be found on the MSDS Section 11.
How can solutions of Cisplatin, Product P4394, be stored?
Sterile solutions in 0.9% sodium chloride protected from light are stable for 28 days at room temperature.
What is the best solvent to use for Cisplatin, Product P4394?
Pharmaceutical injections of cisplatin are in 0.9% sodium chloride at 1 mg/ml. A 0.1% solution in 0.9% sodium chloride solution has a pH range of 4.5-6.0 immediately after preparation and can be adjusted with HCl.
What is the half-life of Cisplatin, Product P4394, in DMSO?
At 37 °C, the half-life of cisplatin in DMSO is 60 minutes. In vivo the half-life of cisplatin is approximately 30 minutes.
Why should DMSO not be used as a solvent for cis-Diammineplatinum (II) dichloride?
The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride. The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity. Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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