D1515
Doxorubicin hydrochloride
98.0-102.0% (HPLC)
Synonym(s):
Adriamycin, DOX, Hydroxydaunorubicin hydrochloride
About This Item
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
98.0-102.0% (HPLC)
form
powder
mp
216 °C (dec.) (lit.)
solubility
water: 50.0-52.0 mg/mL, clear, orange to red
antibiotic activity spectrum
viruses
Mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Information
human ... TOP2A(7153)
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General description
Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damage DNA, proteins, and membranes. It exerts cytotoxic, antitumor, anticancer, and antineoplastic activity and finds application in cancer, metabolomics, cell biology, and biochemical research.
Application
- in cell viability assays
- MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay
- as a drug in polymeric PLGA-based microparticulate drug delivery
- to develop doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
Biochem/physiol Actions
Features and Benefits
- High-quality antibiotic suitable for multiple research applications
- Ideal for Cell Biology, Metabolomics, and Biochemical research.
Preparation Note
Storage and Stability
Other Notes
comparable product
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Regulatory Information
Choose from one of the most recent versions:
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the excitation and emission wavelength for Product D1515, Doxorubicin hydrochloride?
Doxorubicin has excitation maximum at 470 nm and an emission maximum at 585 nm in ethanol.
What is the difference between Doxorubicin hydrochloride Products D1515 and D1317?
Product No. D1317, Doxorubicin hydrochloride solution has been discontinued and is no longer available. We now offer Product No. D1515 which is a powder.
How can I store a solution of Product D1515, Doxorubicin hydrochloride?
Aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at <0.5 mg/mL, with considerable loss of bioactivity. If stored at 25 °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks.
What can be used to make a solution of Product D1515, Doxorubicin hydrochloride?
The solubility of doxorubicin is tested in water (50 mg/mL), yielding a clear orange to red solution.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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