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Key Documents

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Safety Information

C8138

Sigma-Aldrich

Chlorpromazine hydrochloride

≥98% (TLC), powder, D2 dopamine receptor antagonist

Synonym(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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About This Item

Empirical Formula (Hill Notation):
C17H19ClN2S · HCl
CAS Number:
69-09-0
Molecular Weight:
355.33
Beilstein:
3779989
EC Number:
200-701-3
MDL number:
MFCD00012654
UNSPSC Code:
12352200
PubChem Substance ID:
57654045
NACRES:
NA.77
Pricing and availability is not currently available.

Product Name

Chlorpromazine hydrochloride, ≥98% (TLC)

Quality Level

200

Assay

≥98% (TLC)

form

powder

mp

194-196 °C

solubility

water: 50 mg/mL

originator

GlaxoSmithKline

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
466190T119945979
邻甲基苯胺 purum p.a., ≥99.5% (GC)

89610

邻甲基苯胺

邻甲基苯胺 98%

466190

邻甲基苯胺

邻甲苯胺 溶液 0.6 M in glacial acetic acid, contains thiourea as stabilizer

T1199

邻甲苯胺 溶液

邻甲基苯胺 analytical standard

45979

邻甲基苯胺

assay

≥99.5% (GC)

assay

98%

assay

-

assay

-

solubility

H2O: slightly soluble

solubility

H2O: slightly soluble

solubility

-

solubility

H2O: slightly soluble

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

form

liquid

form

liquid

form

-

form

-

mp

−28 °C (lit.)

mp

−28 °C (lit.)

mp

-

mp

−28 °C (lit.)

density

1.008 g/mL at 25 °C (lit.)

density

1.008 g/mL at 25 °C (lit.)

density

-

density

1.008 g/mL at 25 °C (lit.)

Application

Chlorpromazine hydrochloride has been used:
  • as an antagonists for calmodulin kinase[1]
  • as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)[2]
  • as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells[3]

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCW1593
    MKCT3985
    MKCQ9778
    MKCN7684
    MKCL3205

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    Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane
    Dandekar P, et al.
    Journal of Material Chemistry B: Materials for Biology and Medicine, 3(13), 2590-2598 (2015)
    Endocytic pathways used by Andes virus to enter primary human lung endothelial cells
    Chiang CF, et al.
    PLoS ONE, 11(10), e0164768-e0164768 (2016)
    Anne Y Hung et al.
    Journal of neurophysiology, 97(3), 2465-2479 (2007-03-14)
    The translation of prior activity into changes in excitability is essential for memory and the initiation of behavior. After brief synaptic input, the bag cell neurons of Aplysia californica undergo a nearly 30-min afterdischarge to release egg-laying hormone. The present
    Jim Baggen et al.
    Nature communications, 10(1), 3171-3171 (2019-07-20)
    Enteroviruses are a major cause of human disease. Adipose-specific phospholipase A2 (PLA2G16) was recently identified as a pan-enterovirus host factor and potential drug target. In this study, we identify a possible mechanism of PLA2G16 evasion by employing a dual glycan
    Jessica M D'Amico et al.
    Journal of neurophysiology, 109(6), 1473-1484 (2012-12-12)
    In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents
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