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45979

Supelco

o-Toluidine

analytical standard

Synonym(s):

2-Aminotoluene, 2-Methylaniline

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About This Item

Linear Formula:
CH3C6H4NH2
CAS Number:
95-53-4
Molecular Weight:
107.15
Beilstein:
741981
EC Number:
202-429-0
MDL number:
MFCD00007730
UNSPSC Code:
41116107
PubChem Substance ID:
329757033
NACRES:
NA.24

grade

analytical standard

Quality Level

100

vapor density

3.7 (vs air)

vapor pressure

0.26 mmHg ( 25 °C)

autoignition temp.

899 °F

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.572 (lit.)

bp

199-200 °C (lit.)
89-90 °C/11 mmHg (lit.)

mp

−28 °C (lit.)

solubility

H2O: slightly soluble

density

1.008 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

Cc1ccccc1N

InChI

1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3

InChI key

RNVCVTLRINQCPJ-UHFFFAOYSA-N

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General description

o-Toluidine is one of the metabolites of prilocaine and a causative agent of methaemoglobinemia, associated with exceeding doses of prilocaine.

Application

o-Toluidine may be used as a reference standard for the determination of o-toluidine in water samples by gas chromatographic method following solid-phase extraction and derivatization with iodine.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 1B - Eye Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

185.0 °F - closed cup

Flash Point(C)

85 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF3981
BCBS8696
BCBS8696V

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Gas chromatographic determination of aromatic amines in water samples after solid-phase extraction and derivatization with iodine: I. Derivatization.
Schmidt TC, et al.
Journal of Chromatography A, 810(1-2), 161-172 (1998)
Simultaneous determination of lidocaine, prilocaine and the prilocaine metabolite o-toluidine in plasma by high-performance liquid chromatography.
Klein J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 655(1), 83-88 (1994)
Hun-Je Jo et al.
Chemosphere, 70(6), 949-957 (2007-09-26)
In this study, major toxicants in pigment wastewaters (i.e. raw wastewater and effluent) were determined by toxicity identification evaluations (TIEs), and changes in their toxicities due to combined gamma-ray (gamma-ray) and ozone treatments were evaluated. From TIE results using Daphnia
Tania Carreón et al.
Occupational and environmental medicine, 67(5), 348-350 (2009-11-04)
In 1991, the US National Institute for Occupational Safety and Health (NIOSH) reported an increased bladder cancer risk in a cohort of 1749 workers potentially exposed to o-toluidine and aniline at a chemical manufacturing plant. As additional information showed that
Jin Anotai et al.
Journal of hazardous materials, 196, 395-401 (2011-10-19)
A Box-Behnken design (BBD) statistical experimental design was used to investigate the degradation of o-toluidine by the electro-Fenton process. This method can be used to determine the optimal conditions in multivariable systems. Fe(2+) concentration (0.2-1.0mM), H(2)O(2) concentration (1-5mM), pH (2-4)
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