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Merck
CN

215921

Chlorpromazine hydrochloride

≥99% (HPLC), calmodulin-dependent phosphodiesterase inhibitor, crystalline solid

Synonym(s):

Chlorpromazine, Hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19ClN2S · xHCl
CAS Number:
69-09-0
Molecular Weight:
318.86 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00012654

Key Documents

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Product Name

Chlorpromazine, Hydrochloride, Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM).

SMILES string

S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-]

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

description

Merck USA index - 14, 2185

assay

≥99% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

off-white

solubility

methanol: 10 mg/mL
water: 50 mg/mL

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Fe: ≤0.001%
heavy metals: ≤0.002%

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Product does not compete with ATP.
Target IC50: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Disclaimer

Toxicity: Toxic (F)

General description

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50<10 µM), and PLA2.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lee, M.S., et al. 2007. Cancer Res.67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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David W Sanders et al.
eLife, 10 (2021-04-24)
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate replication and evasion of the host immune response. Here, we report that co-culture

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