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Key Documents

Safety Information

C8273

Sigma-Aldrich

Cytochalasin D

from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

Synonym(s):

Lygosporin A, Zygosporin A

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1 G
¥1,006.32
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¥3,242.74
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¥11,849.43

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Available to ship on2025年4月27日Details


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1 G
¥1,006.32
5 G
¥3,242.74
25 G
¥11,849.43

About This Item

Empirical Formula (Hill Notation):
C30H37NO6
CAS Number:
Molecular Weight:
507.62
Beilstein:
1632828
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

¥1,006.32

List Price¥1,597.73Save 37%

Available to ship on2025年4月27日Details


Request a Bulk Order

biological source

Zygosporium mansonii

Quality Level

Assay

≥98% (TLC and HPLC)

form

powder

solubility

DMSO: soluble
ethanol: soluble

antibiotic activity spectrum

fungi

Mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

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1 of 4

This Item
D063243816D5545
grade

for molecular biology

grade

-

grade

for molecular biology

grade

-

assay

≥99.5% (RT)

assay

≥98% (HPLC), ≥99.0% (titration)

assay

900-1100 mmol/L (Titration molarity)

assay

≥99.0% (titration)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

product line

BioUltra

product line

-

product line

BioUltra

product line

BioXtra

form

powder

form

powder

form

liquid

form

powder

mp

41-44 °C (lit.)

mp

41-44 °C (lit.)

mp

-

mp

41-44 °C (lit.)

General description

Cytochalasin D (CytoD) is commonly used to inhibit actin dynamics and study its role in cellular processes. This fungal-derived small organic compound acts as an inhibitor of the interaction between G-actin and cofilin by binding to G-actin. Additionally, CytoD inhibits the binding of cofilin to F-actin and reduces the rate of actin polymerization and depolymerization in living cells.[1]
Cytochalasin D is a cell-permeable fungal toxin. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Cytochalasin D inhibits smooth muscle contraction and insulin-stimulated but not basal transport of glucose.

Application

Cytochalasin D has been used:
  • to treat H9c2 cells to study the relationship between cell stiffness and the F-actin cytoskeleton[2]
  • as inhibitor of receptor-mediated endocytosis to treat oligodendrocyte precursor cells (OPCs) to investigate the effect of inhibiting specific extracellular vesicle (EV) uptake pathways[3]
  • in in vitro embryo culture to artificially activate oocytes[4]

Biochem/physiol Actions

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

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Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Advances of xenogeneic ovarian extracellular matrix hydrogels for in vitro follicle development and oocyte maturation
Frances-Herrero E, et al.
Biomaterials advances (2023)
Hyperglycemia and hyperlipidemia can induce morphophysiological changes in rat cardiac cell line
Varela R, et al.
Biochemistry and Biophysics Reports (2021)
Cytochalasin D acts as an inhibitor of the actin-cofilin interaction
Shoji K, et al.
Biochemical and Biophysical Research Communications (2012)
Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brain
Vanherle S, et al.
Journal of Extracellular Vesicles (2023)
Marie Olliver et al.
The Journal of infectious diseases, 208(9), 1474-1481 (2013-08-08)
Streptococcus pneumoniae forms part of the normal nasopharyngeal flora but can also cause a broad spectrum of inflammatory diseases. Vitamin D has potent effects on human immunity, including induction of antimicrobial peptides and suppression of T-cell proliferation, but its ability

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