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F132

Sigma-Aldrich

Fluoxetine hydrochloride

≥98% (TLC), solid, selective serotonin reuptake inhibitor 

Synonym(s):

Fluoxetine HCl, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac®

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10 MG
CN¥939.00
50 MG
CN¥4,076.71

CN¥939.00

List PriceCN¥1,276.30Save 26%

Available to ship onApril 25, 2025Details

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10 MG
CN¥939.00
50 MG
CN¥4,076.71

About This Item

Empirical Formula (Hill Notation):
C17H18F3NO · HCl
CAS Number:
56296-78-7
Molecular Weight:
345.79
EC Number:
260-101-2
MDL number:
MFCD00214288
UNSPSC Code:
12352200
PubChem Substance ID:
24278096
NACRES:
NA.77

CN¥939.00

List PriceCN¥1,276.30Save 26%

Available to ship onApril 25, 2025Details

Request a Bulk Order

Product Name

Fluoxetine hydrochloride, solid

form

solid

Quality Level

200

color

white

solubility

H2O: 4 mg/mL
DMSO: >5 mg/mL

originator

Eli Lilly

SMILES string

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

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1 of 4

This Item
PHR1394343290F918
Fluoxetine hydrochloride solid

F132

Fluoxetine hydrochloride

Fluoxetine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1394

Fluoxetine Hydrochloride

Fluoxetine, Hydrochloride A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI).

343290

Fluoxetine, Hydrochloride

Fluoxetine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

F918

Fluoxetine hydrochloride solution

form

solid

form

-

form

solid

form

liquid

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

300

solubility

H2O: 4 mg/mL, DMSO: >5 mg/mL

solubility

-

solubility

methanol: 100 mg/mL, water: 5 mg/mL

solubility

-

originator

Eli Lilly

originator

-

originator

-

originator

-

color

white

color

-

color

-

color

-

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Gene Information

human ... SLC6A4(6532)

Gene Information

-

Gene Information

human ... SLC6A4(6532)

General description

Fluoxetine hydrochloride is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac®.[1][2]

Application

Fluoxetine hydrochloride has been used to study its effect on the binding ability of the radiopharmaceutical 123I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([123I]ADAM) to SERT (serotonin transporters) in mice.[2] It has also been used for the chronic treatment of light deprived animals.[3]It has also been used as a serotonin reuptake inhibitor to study its effects on acute stress in fish.[4]

Biochem/physiol Actions

Fluoxetine hydrochloride works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.[2]
Selective serotonin reuptake inhibitor; antidepressant.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under license from Eli Lilly and Company.
Prozac is a registered trademark of Eli Lilly and Co.

Signal Word

Danger

Hazard Statements

H302,H318,H336,H373,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Chaoran Ren et al.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(7), 1163-1175 (2013-02-02)
    Light is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed
    Darlene C Deecher et al.
    The Journal of pharmacology and experimental therapeutics, 318(2), 657-665 (2006-05-06)
    The purpose of this study was to characterize a new chemical entity, desvenlafaxine succinate (DVS). DVS is a novel salt form of the isolated major active metabolite of venlafaxine. Competitive radioligand binding assays were performed using cells expressing either the
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