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227056

Sigma-Aldrich

N,N-Dimethylformamide

anhydrous, 99.8%

Synonym(s):

DMF, NSC 5356

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1 KG
CN¥1,198.93
3 X 1 KG
CN¥3,027.27
5 KG
CN¥3,852.17
12 KG
CN¥9,202.72
25 KG
CN¥12,080.83

CN¥1,198.93

Estimated to ship onApril 11, 2025Details

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1 KG
CN¥1,198.93
3 X 1 KG
CN¥3,027.27
5 KG
CN¥3,852.17
12 KG
CN¥9,202.72
25 KG
CN¥12,080.83

About This Item

Linear Formula:
HCON(CH3)2
CAS Number:
68-12-2
Molecular Weight:
73.09
Beilstein:
605365
EC Number:
200-679-5
MDL number:
MFCD00003284
UNSPSC Code:
12352111
PubChem Substance ID:
57647999
NACRES:
NA.21

CN¥1,198.93

Estimated to ship onApril 11, 2025Details

Request a Bulk Order

grade

anhydrous

Quality Level

300

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

Assay

99.8%

form

liquid

autoignition temp.

833 °F

expl. lim.

15.2 %

impurities

<0.005% water

evapn. residue

<0.0005%

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General description

N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues.[1] It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups.[2]
N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.[2]

Application

N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene].[3] It may be employed as solvent medium for the various organic reduction reactions.[4]
DMF has been used as a solvent in the following processes:
  • Multi-step synthesis of L-azidohomoalanine (L-Aha) during the substitution of the mesylate by sodium azide.[5]
  • Synthesis of phosphine-FLAG®, a detection reagent for metabolic labeling of glycans.[6]
  • Synthesis of per-O-acetylated 6-azidofucose, a per-O-acetylated azido sugar.[6]
Solvent for many hydrophobic organic compounds.

Packaging

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Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

135.5 °F - closed cup

Flash Point(C)

57.5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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    SHBS6327
    SHBS6455
    SHBS5557
    SHBS4662
    CDBG4576

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    X Wang et al.
    Proceedings of the National Academy of Sciences of the United States of America, 96(20), 11081-11084 (1999-09-29)
    Chemotherapy is commonly used in the treatment of cancers. However, the mechanism of action of many of these agents is not well understood. We present the synthesis of a two-photon fluorophore (C625) and its biological application when chemically linked to
    Reference electrode for anhydrous dimethylformamide.
    Marple LW.
    Analytical Chemistry, 39(7), 844-846 (1967)
    A concise and scalable route to L-azidohomoalanine.
    Roth S, et al.
    Nature Protocols, 5(2), 1967-1973 (2010)
    Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation.
    Laughlin ST and Bertozzi CR.
    Nature Protocols, 2(11), 2930-2944 (2007)
    W P Inskeep et al.
    Plant physiology, 77(2), 483-485 (1985-02-01)
    We found inconsistencies in the commonly used data for chlorophyll analysis in 80% acetone. Recently developed extinction coefficients for chlorophyll b in N,N-dimethylformamide (DMF) based on values from 80% acetone are low as a result of these inconsistencies. We determined
    View All Related Papers

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