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PHR1394

Fluoxetine Hydrochloride

Name: Fluoxetine Hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Fluoxetine hydrochloride, FLX, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac^®

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈F₃NO · HCl

CAS Number:

56296-78-7

Molecular Weight:

345.79

EC Number:

260-101-2

MDL number:

MFCD00214288

UNSPSC Code:

41116107

PubChem Substance ID:

329823368

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 797
traceable to Ph. Eur. F0253000
traceable to USP 1279804

API family

fluoxetine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluoxetine Hydrochloride is a selective serotonin-reuptake inhibitor used as an antidepressant. It is also utilized for the treatment of obsessive-compulsive disorders.

Application

Fluoxetine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Selective serotonin reuptake inhibitor; antidepressant.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3045 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

Sold under license from Eli Lilly and Company.

Prozac is a registered trademark of Eli Lilly and Co.

related product

Product No.

Description

Pricing

1279804

Fluoxetine hydrochloride, United States Pharmacopeia (USP) Reference Standard

F0253030

Fluoxetine impurity C, European Pharmacopoeia (EP) Reference Standard

1279826

1279837

1279815

BP797

Fluoxetine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR1953

PHR1952

PHR2041

Signal Word

Danger

Hazard Statements

H302,H318,H336,H373,H410

Precautionary Statements

P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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The interactions between memory processes and emotions are complex. Our previous investigations in the crab Neohelice led to an adaptation of the affective extension of sometimes opponent processes (AESOP) model. The model proposes that emotions generate separate emotive memory traces

Determination of fluoxetine hydrochloride enantiomeric excess using high-performance liquid chromatography with chiral stationary phases

Olsen BA, et al.

Journal of Pharmaceutical and Biomedical Analysis, 17(4), 623-630 (1998)

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Min-Kyung Joo et al.

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Antibiotics are increasingly recognized as causing neuropsychiatric side effects including depression and anxiety. Alterations in central serotonin and 5-HT receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with gastrointestinal disorders. Nevertheless, it is

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Patel S and Patel NJ

Indian Journal of Pharmaceutical Sciences, 71(4), 477-477 (2009)

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