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51120

Sigma-Aldrich

Guanosine 5′-triphosphate sodium salt hydrate

≥90% (HPLC)

Synonym(s):

GTP, GTP-Na⁺ hydrate, 5′-GTP-Na2

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25 MG
¥765.74
100 MG
¥1,960.44
1 G
¥9,324.21

¥765.74

Available to ship on2025年4月27日Details

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25 MG
¥765.74
100 MG
¥1,960.44
1 G
¥9,324.21

About This Item

Empirical Formula (Hill Notation):
C10H16N5O14P3 · xNa+ · yH2O
CAS Number:
56001-37-7
Molecular Weight:
523.18 (anhydrous free acid basis)
Beilstein:
4113439
EC Number:
252-847-2
MDL number:
MFCD00149227
UNSPSC Code:
41106305
PubChem Substance ID:
57651277
NACRES:
NA.51

¥765.74

Available to ship on2025年4月27日Details

Quality Level

100

Assay

≥90% (HPLC)

form

powder

optical activity

[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4

impurities

≤3 mol/mol water (NMR)

shipped in

wet ice

storage temp.

−20°C

SMILES string

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

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5′-三磷酸鸟苷 钠盐 水合物 ≥90% (HPLC)

51120

5′-三磷酸鸟苷 钠盐 水合物

鸟苷5′-三磷酸 钠盐 水合物 ≥95% (HPLC), powder

G8877

鸟苷5′-三磷酸 钠盐 水合物

鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物 ≥85% (HPLC), powder

G0635

鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物

鸟苷 5′-三磷酸盐 三羟甲基氨基甲烷盐 ≥93% (HPLC), powder

G9002

鸟苷 5′-三磷酸盐 三羟甲基氨基甲烷盐

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥85% (HPLC)

assay

≥93% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

impurities

≤3 mol/mol water (NMR)

impurities

-

impurities

-

impurities

-

General description

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:
  • as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.[1]
  • in a solution for channel current recording in cell lines using a voltage-clamp technique.[2]
  • to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.[3]
  • promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC). [4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCL7338
    BCCL8994
    BCCH8324
    BCCG7140
    BCCF4298

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    Lukas Jakob Neukomm et al.
    Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)
    Multicellular organisms use programmed cell death to eliminate unwanted or potentially harmful cells. Improper cell corpse removal can lead to autoimmune diseases. The development of interventional therapies that increase engulfment activity could represent an attractive approach to treat such diseases.
    Hiroaki Kajiho et al.
    The Journal of biological chemistry, 286(27), 24364-24373 (2011-05-19)
    The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active forms, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing guanine nucleotide exchange
    Gyu-Sang Hong et al.
    Neuron, 94(2), 271-273 (2017-04-21)
    Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.
    Angel Baudon et al.
    STAR protocols, 3(1), 101159-101159 (2022-02-25)
    Astrocytes are glial cells that exhibit calcium signaling-mediated activity. Here, we present a protocol to monitor and manipulate astrocyte calcium activity from mouse amygdala slices. In the first part of this protocol, we describe the procedure of astrocyte calcium imaging.
    S P Gilbert et al.
    Biochemistry, 32(17), 4677-4684 (1993-05-04)
    The Drosophila kinesin heavy-chain gene was truncated to obtain the N-terminal 401 amino acid motor domain (designated K401) containing both the microtubule and ATP binding sites. The plasmid construct with the truncated kinesin gene was used to transform Escherichia coli.
    View All Related Papers

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