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Sigma-Aldrich

Guanosine 5′-triphosphate sodium salt hydrate

≥90% (HPLC)

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Synonym(s):
GTP, GTP-Na⁺ hydrate, 5′-GTP-Na2
Empirical Formula (Hill Notation):
C10H16N5O14P3 · xNa+ · yH2O
CAS Number:
36051-31-7
Molecular Weight:
523.18 (anhydrous free acid basis)
Beilstein:
4113439
EC Number:
252-847-2
MDL number:
MFCD00149227
UNSPSC Code:
41106305
PubChem Substance ID:
57651277
NACRES:
NA.51

Quality Level

100

Assay

≥90% (HPLC)

form

powder

optical activity

[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4

impurities

≤3 mol/mol water (NMR)

shipped in

wet ice

storage temp.

−20°C

SMILES string

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

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General description

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:
  • as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
  • in a solution for channel current recording in cell lines using a voltage-clamp technique.
  • to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
  • promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Gyu-Sang Hong et al.
Neuron, 94(2), 271-273 (2017-04-21)
Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.
Hiroaki Kajiho et al.
The Journal of biological chemistry, 286(27), 24364-24373 (2011-05-19)
The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active forms, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing guanine nucleotide exchange
M Uriarte et al.
The Biochemical journal, 293 ( Pt 1), 93-100 (1993-07-01)
A glycoprotein fraction was isolated from rat liver membranes by affinity chromatography on immobilized wheat-germ lectin. Incubation of this fraction with MgATP or MgGTP resulted in a sequential phosphorylation and dephosphorylation of a complex of three polypeptides (118, 128 and
Fu-Jung Chang et al.
The Journal of biological chemistry, 280(12), 11513-11519 (2005-01-15)
The mechanism of desensitization of the nitric oxide (NO) receptor (alpha1.beta1 isoform of soluble guanylyl cyclase, sGC) is not known. Models of the structure of alpha1.beta1, based on the x-ray crystal structure of adenylyl cyclase (AC) suggest the existence of
A Davis et al.
Biochemistry, 32(34), 8823-8835 (1993-08-31)
We describe a method for isolating milligram quantities of assembly-competent tubulin from the budding yeast Saccharomyces cerevisiae. The tubulin is > 95% purified and free of contaminating enzyme activities. As a result, it has been possible to determine the yeast
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