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30432

Sigma-Aldrich

Dansylcadaverine

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

Synonym(s):

N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine

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250 REACTIONS
¥3,107.76
1250 REACTIONS
¥14,336.31

¥3,107.76

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250 REACTIONS
¥3,107.76
1250 REACTIONS
¥14,336.31

About This Item

Empirical Formula (Hill Notation):
C17H25N3O2S
CAS Number:
10121-91-2
Molecular Weight:
335.46
Beilstein:
2951070
EC Number:
233-326-9
MDL number:
MFCD00042704
UNSPSC Code:
12352108
PubChem Substance ID:
57648439
NACRES:
NA.32

¥3,107.76

Please contact Customer Service for Availability
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product line

BioReagent

Assay

≥99.0% (HPLC)

mp

137-140 °C

fluorescence

λex 335 nm; λem 518 nm in methanol
λex 338 nm; λem 500 nm (Reaction product)

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN

InChI

1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3

InChI key

MLEBFEHOJICQQS-UHFFFAOYSA-N

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This Item
KCQS00KCQS01KCQS07
KiCqStart® SYBR® Green qPCR ReadyMix™ with ROX™ for ABI instruments

KCQS02

KiCqStart® SYBR® Green qPCR ReadyMix™

KiCqStart® SYBR® Green qPCR ReadyMix™ For Bio-Rad, Cepheid, Eppendorf, Illumina, Corbett, and Roche systems

KCQS00

KiCqStart® SYBR® Green qPCR ReadyMix™

KiCqStart® SYBR® Green qPCR ReadyMix™ Low ROX™, for ABI and Stratagene instruments

KCQS01

KiCqStart® SYBR® Green qPCR ReadyMix™

KiCqStart® One-Step Probe RT-qPCR ReadyMix™ for Bio-Rad, Cepheid, Eppendorf, Illumina, Corbett, and Roche systems

KCQS07

KiCqStart® One-Step Probe RT-qPCR ReadyMix™

form

liquid

form

liquid

form

liquid

form

liquid

usage

sufficient for 1250 reactions

usage

sufficient for 1250 reactions, sufficient for 250 reactions, sufficient for 5000 reactions

usage

sufficient for 1250 reactions, sufficient for 250 reactions, sufficient for 5000 reactions

usage

sufficient for 500 reactions

feature

dNTPs included

feature

dNTPs included, hotstart

feature

dNTPs included, hotstart

feature

dNTPs included, hotstart

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

color

colorless

color

colorless

color

colorless

color

light blue

Application

Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Biochem/physiol Actions

Inhibitor of the fibrin-stabilizing fator;[1] Inhibitor of epidermal growth factor (EGF) internalization;[2] Fluorescent substrate for the assay of transamidating enzymes.[3][4]
The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.
air sensitive, handled under inert gas

Other Notes

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    H T Haigler et al.
    The Journal of biological chemistry, 255(4), 1239-1241 (1980-02-25)
    The binding and internalization of 125I-epidermal growth factor (125I-EGF) was studied in cultures of BALB 3T3 cells using a novel method that involved removal of cell-surface hormone by treatment with acetic acid under conditions that did not remove internalized hormone.
    Qi Jiang et al.
    The Journal of urology, 188(4), 1361-1368 (2012-08-22)
    Androgen receptor has a critical role in prostate cancer development and progression. Cell death via autophagy may also contribute to prostate cancer progression. We determined the role and regulatory effects of androgen receptor on the autophagy process of prostate cancer
    S N Murthy et al.
    The Journal of biological chemistry, 269(36), 22907-22911 (1994-09-09)
    Elevating the intracellular concentration of Ca2+ ions in human erythrocytes leads to the formation of membrane-associated polymers, composed of skeletal and cytoplasmic proteins. The anion transporter band 3 serves as a membrane anchor for this N epsilon-(gamma-glutamyl)lysine cross-linked polymer. The
    Melissa S Hillwig et al.
    Proceedings of the National Academy of Sciences of the United States of America, 108(3), 1093-1098 (2011-01-05)
    RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogenetic analyses suggest that they may carry out an important housekeeping role. However, the nature of this role has been elusive. Here we show that RNS2, an
    Transamidating enzymes. I. Rapid chromatographic assays.
    L Lorand et al.
    Analytical biochemistry, 44(1), 207-220 (1971-11-01)
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