SyTracks Carbon Monoxide Generator FAQs

COgen (Product No. 745022) is a bench-stable and easy to handle solid from which a predetermined amount of carbon monoxide (CO) can be released in a highly controlled manner.

COware (Product No. STW1) is a sealable, two-chamber glassware consisting of two reaction vessels connected by a bridge allowing gas-transfer between the chambers.

COgen combined with COware affords the SyTracks COgenerator system, a safe system for the efficient handling and application of CO at 14–46 psi (1–3 bars) for any carbonylation purpose.

When the SyTracks COgenerator is used, the direct handling of CO is avoided. This provides a safe and simple method of performing carbonylation chemistry.

1. The need for hazardous pressurized CO canisters is avoided.
   
2. The COgenerator provides a more reliable and robust CO delivery than a balloon of CO.
   
3. Expensive and cumbersome autoclave systems are avoided, at the same time providing the benefit of operating at slightly elevated pressures.
   
4. Cost-effective isotope labeling with ¹³CO.

CO produced from COgen corresponds directly to CO being delivered from a pressurized canister. When the same solvent is employed in the COgenerator as in the reaction chamber, no cross-contamination is likely to occur.

Setup in a glovebox is not required due to the unique design of COware. The combination of the PTFE coated silicone seal with the COware stabilizing discs provides a pierceable and resealable closure system, which allows for purging with an inert gas if needed before heating the reaction.

No, the COgenerator is tolerant to ambient air.

As COgen and COware presents a standard reaction flask solution to reactions with gases and fits into any fumehood, it is highly suitable for any research by medicinal and/or developmental chemist within academia as well as industry.

1. Almost any given palladium(0) or palladium (II) source. CO will be released at catalyst loadings down to 0.1 mol %.
   
2. [(t-Bu)₃PH]BF₄ (Product No. 578940)
   
3. Cy₂NME (Product No. 294942), alternatively; Et₃N or i-Pr₂NEt.
   
4. Any aprotic solvent such as toluene, dioxane, DME, THF, CPME, DMF, NMP, paraffin, isopropyl acetate, etc.

A high-boiling aprotic solvent is chosen for CO generation.

For 0.5 mmol substrate in the reaction chamber, 0.75 mmol (1.5 equivalents) of COgen is typically applied. To release CO from 0.75 mmol of COgen, 0.0075 mmol Pd(dba)₂ (1 mol %), 0.0075 mmol [(t-Bu)₃PH]BF₄ (1 mol %), 1.125 mmol Cy₂NMe, and 3 mL of toluene are used.

Using typical conditions: (toluene, [(t-Bu)₃PH]BF₄, Pd(dba)₂, 80 ^oC, Cy₂NMe) CO is completely released within 10 minutes.

COware should not be operated above 60 psi.

The maximum loading of COgen is related to the maximum operating pressure. For COware volume of 20 mL and disregarding heating above ambient temperature, gaseous byproducts, and solvent vapor pressure: With a combined volume of reagents, starting materials, and solvents in the two chambers of 6 mL, a headspace volume of 14 mL results. Loading 1.9 mmol of COgen gives 46 mL CO gas and thus results in a combined internal pressure of 60 psi (60 mL gas in a 14 mL volume).