Chromatography Systems for Bioprocessing
Single-use and multi-use chromatography systems are foundational to downstream purification in biopharmaceutical manufacturing. From bench-scale process development to commercial-scale biomanufacturing, our systems facilitate regulatory compliance and deliver consistent performance across batch and continuous chromatography workflows.
Our comprehensive portfolio of columns, affinity, ion exchange, and membrane chromatography resins and adsorbers — paired with applications support and process validation services — enables you to efficiently purify monoclonal antibodies (mAbs), recombinant proteins, viral vectors, and antibody-drug conjugates (ADCs). Seamlessly translate method development into scalable GMP processes, improving yield, process economics, and time to market.
Key benefits and features
Achieve high-resolution, reproducible separations with confidence.
From pilot-scale to full commercial manufacturing, scale seamlessly with configurable single-use options.
Ensure consistent performance from development through commercial production with our dedicated technical experts.
Chromatography systems
Mobius® Chrom systems
Flexible, automated, single- use chromatography systems that enable consistent and reliable separation and purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scales.
Mobius® Multi Column Capture systems
Fully automated, single-use solution to operate continuous closed capture chromatography. It manages process parameters in real time with reference to changing column load, surge feed tank load, and monitoring resin performance.
CoPrime® Biochromatography systems
Designed to achieve optimum separation and purification of monoclonal antibodies, vaccines, plasma, and therapeutic proteins. The systems support rapid scale-up and are ideally suited for pilot and process scale.
Our chromatography experts can guide you to the right solution for your specific process needs.
Find the right chromatography system for your needs
Common Control Platform® (CCP®)
Common Control Platform® (CCP®) is a common software platform across our family of fully automated systems. It controls bioprocessing operations, simplifies software management, and securely manages data. Designed to operate in GMP environments, it is developed in line with GAMP® 5 recommendations for automation software and facilitates 21 CFR Part 11 compliance for electronic records and signatures.
Available scales
Chromatography columns and resins for bioprocessing
Chromatography columns are critical to the successful separation of your valuable molecules. We provide columns from lab scale to pilot and process scale, delivering robust and consistent performance with the processing flexibility you need for anything from screening to large-scale production.
Affinity chromatography is a powerful purification technology that separates biomolecules through highly selective interactions. This exceptional selectivity streamlines impurity removal and achieves high purity in a single step. Our portfolio of affinity resins addresses diverse process needs and provides the purification tools you need from platform manufacturing to next-generation applications.
Bioprocessing development expertise and support
We bring together bioprocessing expertise, manufacturing technologies, and global infrastructure to support your process development and manufacturing needs, including chromatography steps. Learn more on how we can support you from facility design to implementation.
Frequently asked questions
What types of chromatography systems do you offer, and which applications are they best suited for?
We offer both multi-use and single-use chromatography systems designed to support the full biopharma purification workflow.
CoPrime® Biochromatography systems are multi-use, automated LCs at 3, 20 and 40 L capacity. They offer optimum separation and purification of mAbs, vaccines, plasma and therapeutic proteins at pilot and process scale.
Mobius® Chrom 2, 10 and 20 are single-use, automated systems. They offer flexible purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scale (up to 2,000 L).
Mobius® Multi Column Capture (MCC) System is a single-use, continuous, 3-column chromatography system. It enables intensified, continuous capture of mAbs from fed-batch or perfusion bioreactors (50 L–2,000 L) and dramatically reduces resin and buffer consumption.
What scales can your systems handle (lab, pilot, production)?
CoPrime® biochromatography systems
Fully automated, multi-use stainless steel liquid chromatography (LC) system designed for pilot through commercial manufacturing.
Mobius® Chrom Systems (Single-Use)
The Mobius® Chrom family is a harmonized suite of single-use, fully automated chromatography systems enabling seamless, linear scale-up or scale-down across the entire clinical-to-commercial journey without revalidation of process recipes. It covers processes from 50 L to 2,000 L.
Mobius® Multi Column Capture (MCC) System (Single-Use, Continuous)
The MCC sits alongside the Chrom systems as a dedicated continuous capture solution with three columns in series, fundamentally changing the economics of the Protein A capture step.
What resins/columns are compatible with your platform and can you support specific products we use?
Our chromatography systems are compatible with our full portfolio of resins and column formats, covering every step of the purification workflow.
Related webinars
Multi-column chromatography is a bioprocessing technique where multiple columns are loaded in series and then cycled for elution, regeneration, and equilibration.
The benefits of a novel Protein A affinity membrane, used as a high productivity, truly single-use chromatography platform for intensified mAb purification.
CEX flow-through frontal chromatography for the removal of mAb aggregates as well as the conditions that influence the removal of these aggregates.
An overview of custom affinity chromatography technologies for vaccine purification.
Related documents
- Application note: Multi-column chromatography for efficient polishing purification
The studies in this application note focus on Ion Exchange (IEX) chromatography in bind/elute mode using the Mobius® Multi Column Capture system.
- Application note: Efficient protein A capture intensified processes
Assess the efficiency of continuous mAb capture from a clarified and filtered harvest cell culture fluid (HCCF), using the Mobius® Multi Column Capture system and evaluate process scalability.
- Application note: In-line dilution capabilities of Mobius® multi column capture system for effective buffer management strategies
Enhancing Intensified Chromatography Performance through Automated Buffer Dilution
- Application note: Process development and scale-up strategy for the Mobius® Multi Column Capture system
A methodology for developing and scaling up a process for a multi-column capture operation using the Mobius® Multi Column Capture.
- Data sheet: Mobius® Multi Column Capture system
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- Data sheet: Mobius® Chrom systems
The Mobius® Chrom systems are a flexible, automated, single-use chromatography systems that enable consistent and reliable separation and purification.
- Application note: Multi-Column Capture
Prototype tests for monoclonal antibody capture during project nextBioPharmDSP (Horizon 2020).
- Technical brief: Mobius® Breez Microbioreactor
Mixing and gas transfer in the Mobius® Breez Microbioreactor – How it works?
- Spare parts list: Mobius® Multi Column Capture system
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Performance guide: Mobius® Multi Column Capture system
The purpose of this document is to describe the performance of the Mobius® Multi Column Capture system and highlight the working principles of its innovative features.
- Data sheet: CoPrime® Biochromatography process-scale system
Fully automated, configurable systems for biopharmaceutical manufacturing and cGMP process scale applications.
- Poster: Horizon 2020 - Fully connected single-use downstream platform for mAb production
Within the biopharmaceutical industry, there is a significant shift toward higher productivity processes resulting in improved economics without compromising robustness. Therefore, integrated continuous production technologies are of greatest interest.
- Brochure: Process development and drug manufacturing
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
- Application note: Implementation of Multi-Column Chromatography systems
The Multi-Column Capture (MCC) system enables efficient primary capture through three column operation, supporting continuous feedstream processing.
- Performance guide: Mobius® Chrom 10 system
Discover Mobius® Chrom 10 system’s key performance highlights for scalable chromatography in clinical and commercial purification.
- Performance Guide: Mobius® Chrom 2 System
Discover the Mobius® Chrom 2 system, fully automated with operational flexibility, designed to reduce cross-contamination in scalable chromatography.
Related articles
- Learn strategies for designing flexible, modular biomanufacturing facilities, and how single-use technologies and automation enable scalable production.
- Learn what to include in User Requirement Specifications (URS) and how it supports design, qualification, and regulatory compliance for scalable single-use downstream processing systems.
- Explore computer system validation (CSV) in pharma, including core requirements, data integrity, risk management, best practices, and the shift to CSA.
