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Affinity Chromatography Resins

A laboratory setting showcasing the tools and chemicals used in affinity chromatography. In the foreground, three bottles labeled with hazard symbols indicate the presence of flammable and corrosive substances, essential for selective biochemical interactions and purification processes. In the background, a scientist in a lab coat is engaged with complex equipment, likely related to large-scale manufacturing and process development in affinity chromatography.

Affinity chromatography is a powerful purification technology that separates biomolecules through highly selective interactions. This exceptional selectivity streamlines impurity removal and achieves high purity in a single step.

Our portfolio of affinity resins addresses diverse process needs and provides the purification tools you need from platform manufacturing to next-generation applications.

Amsphere® Protein A Resins Are Now Part of Our Portfolio

Amsphere® resins are well-established Protein A resins for efficient purification of antibodies and their derivatives. This expanded resin portfolio offers more options for you to optimize process performance, enhance productivity, and improve economics. 

Section Overview

Protein A Affinity Resins for Antibody Capture

Amsphere® A+: Next-generation Protein A affinity resin engineered for superior process efficiency

  • Outstanding dynamic binding capacity optimized for high-titer and intensified processes
  • Excellent durability and caustic stability for enhanced bioburden control
  • Superior pressure-flow properties and impurity removal ability

Amsphere® A3: Well-established high-capacity Protein A resin with an extensive track record in clinical and commercial processes.

  • High dynamic binding capacity optimized for high-titer processes and process intensification
  •  Excellent productivity and cost-of-goods optimization at manufacturing scale
  • Platform affinity resin for standard mAbs and antibody derivatives including Bi-specifics, Fc-fusion, fragments, VHH single-domain antibodies

Eshmuno® A: Proven and reliable Protein A resin designed for robust and scalable monoclonal antibody purification.

  • High dynamic binding capacity and reliable performance across a wide operating window and process conditions
  • Caustic stability for enhanced bioburden control
  • Excellent pressure-flow properties and packing convenience at large scale

To request a sample contact us.

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Affinity Resins for Plasma Purification

Eshmuno® P anti-A and anti-B resins effectively remove anti-A and anti-B isoagglutinin antibodies in plasma-derived Immunoglobulin (Ig) processes, which has been associated with increased patient risk for hemolysis.

Affinity Resins for Protein Purification

Fractogel® Chelate resin offers efficient and cost-effective separation of proteins and peptides, especially proteins with exposed histidine, cysteine, and tryptophan residues, including histidine-tagged proteins.

Highlights And Support Available

High-performance resins for purification of antibodies and antibody derivatives

Extensive technical and application expertise to support process development and scale-up

Global manufacturing and supply chain network ensuring supply resilience and operational continuity

Regulatory excellence with the EMPROVE® Program providing full transparency and comprehensive documentation to support qualification, risk assessment, and process optimization to simplify your compliance needs.

Related Resources

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Related Webinars

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An open laptop with a colorful display featuring a stylized human figure in blue on the right and a pink rectangle on the left against a yellow background.

Addressing Immunoglobulin (Ig) Purification Challenges with Chromatographic Technologies

Strategies to address Immunoglobulin purification challenges by using Ion Exchange and Affinity chromatography media to enhance both purity & yield.

An open laptop with a colorful display featuring a stylized human figure in blue on the right and a pink rectangle on the left against a yellow background.

Protein A Affinity Chromatography: How to Capitalize on its Purification Potential

Learn productivity & COGs calculations of Protein A affinity chromatography resin at production scale, including best practice strategies to lower costs.

An open laptop with a colorful display featuring a stylized human figure in blue on the right and a pink rectangle on the left against a yellow background.

Extractables Profiles for Chromatography Resins – Adapted Approach of Upcoming USP

This webinar will cover our study design for extractables profiles of chromatography resins within our Emprove® Program.

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