Multi-column chromatography is a bioprocessing technique where multiple columns are loaded in series and then cycled for elution, regeneration, and equilibration. This allows fuller utilization of the potential resin binding capacity, rapid cycling of much smaller columns and, with careful scheduling, a continuous elution stream suitable for continuous or connected bioprocessing applications. While very effective at increasing operational efficiency, especially with Protein A primary capture of monoclonal antibodies, this technique does present challenges regarding system design, automation, and control due to the increased complexity of the single-use flow path.
In this webinar, you will learn:
- The definition of multi-column chromatography
- How MCC differs from standard chromatography in practice
- System design, concerns, and constraints
- Use case on a process scale implementation
Speaker
Paul Beckett
Merck
Senior Manager, Downstream Technologies, BioContinuum™ Platform
Paul holds a B.S. in biochemistry from Imperial College London and has an M.S. and Ph.D. in biochemical engineering from University College London. Paul has worked in the pharmaceutical industry for 20 years and has held a number of roles in this capacity, including managing bioprocesses for early phase clinical material, CMC regulatory affairs consultancy, and downstream bioprocessing technology consultancy. Currently, Paul is a senior manager responsible for the DSP strategy for the BioContinuum™ next-generation processing platform.
Pharma and biopharma manufacturing
- Downstream Processing
Duration:1h
Language:English
Session 1:presented September 22, 2022
To continue reading please sign in or create an account.
Don't Have An Account?
