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一般描述
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).
应用
LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.
特点和优势
Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:
- Apotosis
- G Proteins & Cyclic Nucleotides
- Gene Regulation & Expression
- Ion Channels
- Lipid Signaling
- Multi-drug Resistance
- Neurotransmission
- Phosphorylation
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Sigma-RBI Product Number (for easy re-order)
- Rack Position
其他说明
For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.
法律信息
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery
Young J, et al.
SLAS discovery, 23(8), 790-806 (2018)
Kurumi Y Horiuchi et al.
Assay and drug development technologies, 11(4), 227-236 (2013-04-06)
Epigenetic modifications play a crucial role in human diseases. Unlike genetic mutations, however, they do not change the underlying DNA sequences. Epigenetic phenomena have gained increased attention in the field of cancer research, with many studies indicating that they are
James Robinson et al.
Assay and drug development technologies, 11(8), 468-477 (2013-10-15)
The galanin 3 receptor (GalR3) belongs to the large G protein-coupled receptor (GPCR) family of proteins. GalR3 and two other closely related receptors, GalR1 and GalR2, together with their endogenous ligand galanin, are involved in a variety of physiological and
Nicolas Wyhs et al.
Journal of biomolecular screening, 19(7), 1060-1069 (2014-03-13)
Methylated DNA binding proteins such as Methyl-CpG Binding Domain Protein 2 (MBD2) can transduce DNA methylation alterations into a repressive signal by recruiting transcriptional co-repressor complexes. Interfering with MBD2 could lead to reactivation of tumor suppressor genes and therefore represents
商品
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
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