推荐产品
一般描述
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).
应用
LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.
特点和优势
Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:
- Apotosis
- G Proteins & Cyclic Nucleotides
- Gene Regulation & Expression
- Ion Channels
- Lipid Signaling
- Multi-drug Resistance
- Neurotransmission
- Phosphorylation
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Sigma-RBI Product Number (for easy re-order)
- Rack Position
其他说明
For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.
法律信息
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
法规信息
新产品
Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
Jayme L Dahlin et al.
PloS one, 8(11), e78877-e78877 (2013-11-22)
The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic resistance in yeast and pathogenic
Nicolas Wyhs et al.
Journal of biomolecular screening, 19(7), 1060-1069 (2014-03-13)
Methylated DNA binding proteins such as Methyl-CpG Binding Domain Protein 2 (MBD2) can transduce DNA methylation alterations into a repressive signal by recruiting transcriptional co-repressor complexes. Interfering with MBD2 could lead to reactivation of tumor suppressor genes and therefore represents
John S Lazo et al.
Molecular pharmacology, 72(1), 1-7 (2007-04-05)
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery
Young J, et al.
SLAS discovery, 23(8), 790-806 (2018)
商品
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
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