form
liquid
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
shipped in
dry ice
storage temp.
−20°C
Quality Level
Application
LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.
Features and Benefits
Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:
- Apotosis
- G Proteins & Cyclic Nucleotides
- Gene Regulation & Expression
- Ion Channels
- Lipid Signaling
- Multi-drug Resistance
- Neurotransmission
- Phosphorylation
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Sigma-RBI Product Number (for easy re-order)
- Rack Position
General description
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).
Other Notes
For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.
Legal Information
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
法规信息
新产品
此项目有
Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery
Young J, et al.
SLAS discovery, 23(8), 790-806 (2018)
Kurumi Y Horiuchi et al.
Assay and drug development technologies, 11(4), 227-236 (2013-04-06)
Epigenetic modifications play a crucial role in human diseases. Unlike genetic mutations, however, they do not change the underlying DNA sequences. Epigenetic phenomena have gained increased attention in the field of cancer research, with many studies indicating that they are
James Robinson et al.
Assay and drug development technologies, 11(8), 468-477 (2013-10-15)
The galanin 3 receptor (GalR3) belongs to the large G protein-coupled receptor (GPCR) family of proteins. GalR3 and two other closely related receptors, GalR1 and GalR2, together with their endogenous ligand galanin, are involved in a variety of physiological and
Jayme L Dahlin et al.
PloS one, 8(11), e78877-e78877 (2013-11-22)
The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic resistance in yeast and pathogenic
商品
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
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