HPA047192
Anti-CLCA2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-CLCRG2
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关于此项目
Human Protein Atlas Number:
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:500-1:1000
immunogen sequence
EELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLCA2(9635)
General description
Calcium activated chloride channel 2(CLCA2) is an integral transmembrane protein. CLCA2 is induced during human mammary epithelial cell differentiation. CLCA2 is located on human chromosome 1p22.3.
Immunogen
chloride channel accessory 2
Application
Anti-CLCA2 antibody has been used to detect CLCA2 in nasopharyngeal carcinoma(NPC) cell lines. It also has been used to detect CLCA2 in SiHa cells and tumor tissues using western blotting.
Biochem/physiol Actions
CLCA2 regulates cell migration and invasion and is also associated with p53 tumour suppressor genes. CCLA2 helps to maintain corneal transparency due to the high and tissue specific expression of CCLA2 gene in human corneal epithelium. CLCA2 plays an important role in suppressing breast cancer. CLCA2 is used as an effective immunohistochemical marker for distinguishing primary SCC and primary ADC of lungs.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Other Notes
Corresponding Antigen APREST71988
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
CLCA2, a novel RUNX1 partner gene in a therapy-related leukemia with t (1; 21)(p22; q22)
Giguere A, et al.
Cancer Genetics and Cytogenetics, 202(2), 94-100 (2010)
CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung
Shinmura,, et al.
Disease Markers, 2014 (2014)
CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer
Li, Xiuro, et al.
Oncogene, 23(7), 1474-1474 (2004)
Yuan-Yuan Qiang et al.
Journal of experimental & clinical cancer research : CR, 37(1), 34-34 (2018-02-22)
CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional and molecular mechanisms by which CLCA2 influences
Peijin Zhang et al.
Experimental and therapeutic medicine, 22(1), 776-776 (2021-06-01)
Ca2+-activated Cl- channel A2 (CLCA2), a tumor suppressor, is associated with the development of several cancers. However, little is known about CLCA2 in human cervical cancer. Therefore, the aim of the present study was to investigate the effects of CLCA2
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