生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
形式
buffered aqueous glycerol solution
种属反应性
human
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
技术
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200
免疫原序列
LSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQV
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TCF21(6943)
一般描述
Transcription factor TCF21 (TCF21) or capsulin, expressed in proepicardial cells is mapped to human chromosome 6q23.2.
免疫原
transcription factor 21 recombinant protein epitope signature tag (PrEST)
应用
Anti-TCF21 antibody produced in rabbit has been used in:
- immunofluorescence
- flow cytometry
- chromatin immunoprecipitation
生化/生理作用
Transcription factor TCF21 (TCF21) regulates mesenchymal-to-epithelial differentiation and smooth muscle cells (SMCs) phenotypic modulation. The deletion of TCF21 gene leads to SMC upregulation. Hypermethylation of TCF21 is implicated in non-small cell lung cancer (NSCLC). TCF21 is a tumor suppressor and is involved in the invasion and metastasis. Elevated expression of TCF21 leads to hepatocellular cancer suppression. It also elicits anti-angiogenic activity in cholangiocarcinoma. TCF21 locus is also associated with coronary heart disease(CAD).
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST85233
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
法规信息
常规特殊物品
Olga Sazonova et al.
PLoS genetics, 11(5), e1005202-e1005202 (2015-05-29)
To functionally link coronary artery disease (CAD) causal genes identified by genome wide association studies (GWAS), and to investigate the cellular and molecular mechanisms of atherosclerosis, we have used chromatin immunoprecipitation sequencing (ChIP-Seq) with the CAD associated transcription factor TCF21
Felix Kliewe et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 55(S4), 48-67 (2021-06-21)
Podocyte differentiation is essential for proper blood filtration in the kidney. It is well known that transcription factors play an essential role to maintain the differentiation of podocytes. The present study is focused on the basic helix-loop-helix (bHLH) transcription factor
Juyong Brian Kim et al.
PLoS genetics, 13(5), e1006750-e1006750 (2017-05-10)
Both environmental factors and genetic loci have been associated with coronary artery disease (CAD), however gene-gene and gene-environment interactions that might identify molecular mechanisms of risk are not easily studied by human genetic approaches. We have previously identified the transcription
Thomas J Streef et al.
Stem cell reports, 18(7), 1421-1435 (2023-07-01)
The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute to adult cardiac repair. The cell fate
Juyong Brian Kim et al.
Circulation, 142(6), 575-590 (2020-05-23)
Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated in coronary artery disease risk. We hypothesized that AHR can affect
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