HPA001164

抗-MKI67 兔抗

Name: 抗-MKI67 兔抗
Brand: SIGMA

Ab2, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-MIB-, 抗-PPP1R105

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

Human Protein Atlas Number:

HPA001164

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC

Citations:

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200

immunogen sequence

DGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDVITIIDRSFRYENESLQSGRKSTEFPRKIREQEPARRVSRSSFSSDPDEKAQDSKAYSKITEGKVSGNPQVHI

UniProt accession no.

P46013

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MKI67(4288)

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Immunogen

抗原KI-67重组蛋白表位信号标签（PrEST）

Application

由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证，因此受到业内最广泛的表征支持。

人类蛋白质图集项目可以分为三大部分：人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证，并且通过近期人类细胞图谱项目的努力，许多抗体已经过免疫荧光分析的表征，从而绘制人类蛋白质组图谱，不仅是在组织水平上，现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接，可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies^® 抗体的实验方案和其他有用信息。

Biochem/physiol Actions

KI-67抗原是一种由人类 MKI67 基因编码的蛋白质，位于第 10 号染色体上。它被用作首选的增殖生物标志物，在乳腺癌中具有预后和预测价值。它还有助于预测乳腺癌患者随分子亚型变化对新辅助化疗的反应，反映了有关 Ki-67 的日常工作及其令人印象深刻的潜力。

Features and Benefits

Prestige Antibodies^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies^®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品，可在链接部分找到。

每种Prestige 抗体的检测方法如下：

44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
364个人重组蛋白片段的蛋白阵列。

Physical form

磷酸盐缓冲盐水溶液，pH 7.2，含有40%甘油和0.02%叠氮化钠

Other Notes

相应抗原APREST79721

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

低风险生物材料

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

R00632

R000632

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Can ki-67 play a role in prediction of breast cancer patients' response to neoadjuvant chemotherapy?

Juhasz-Böss Ingolf et al.

BioMed research international, 2014, 628217-628217 (2014-05-02)

Currently the choice of breast cancer therapy is based on prognostic factors. The proliferation marker Ki-67 is used increasingly to determine the method of therapy. The current study analyses the predictive value of Ki-67 in foreseeing breast cancer patients' responses

A novel model for Ki67 assessment in breast cancer.

Quinci Romero et al.

Diagnostic pathology, 9, 118-118 (2014-06-18)

Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. One

Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10.

D M Schonk et al.

Human genetics, 83(3), 297-299 (1989-10-01)

The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the

SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization.

Tawna L Mangosh et al.

Molecular cancer research : MCR, 19(2), 301-316 (2020-11-15)

In advanced prostate cancer, resistance to androgen deprivation therapy is achieved through numerous mechanisms, including loss of the androgen receptor (AR) allowing for AR-independent growth. Therapeutic options are limited for AR-independent castration-resistant prostate cancer (CRPC), and defining mechanisms critical for

Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I.

Andrea Esposito et al.

Cancers, 14(9) (2022-05-15)

Tumor dormancy is the extended period during which patients are asymptomatic before recurrence, and it represents a difficult phenomenon to target pharmacologically. The relapse of tumors, for instance arising from the interruption of dormant metastases, is frequently observed in ovarian

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抗-MKI67 兔抗

Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

选择尺寸

关于此项目

主要文件

属性

biological source

conjugate

antibody form

antibody product type

clone

product line

form

species reactivity

enhanced validation

technique(s)

immunogen sequence

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Immunogen

Application

Biochem/physiol Actions

Features and Benefits

Physical form

Other Notes

Legal Information

Disclaimer

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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Ab2, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution