UBE3A
ubiquitin protein ligase E3A
别名:
ANCR, AS, E6-AP, EPVE6AP, HPVE6A
物种:
Human UBE3A (7337), Mouse Ube3a (22215), Rat Ube3a (361585), naked mole-rat Ube3a (101709173), Domestic Rabbit UBE3A (100342825), sheep UBE3A (101114391), domestic guinea pig Ube3a (100730511), dog UBE3A (479010), domestic cat UBE3A (101089941), cow UBE3A (533136) ...展开
UniProtKB ID:
基因ID:
- Human(7337) Summary: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(22215) ubiquitin protein ligase E3A
- Rat(361585) ubiquitin protein ligase E3A
- naked mole-rat(101709173) ubiquitin protein ligase E3A
- Domestic Rabbit(100342825) ubiquitin protein ligase E3A
- sheep(101114391) ubiquitin protein ligase E3A
- domestic guinea pig(100730511) ubiquitin protein ligase E3A
- dog(479010) ubiquitin protein ligase E3A
- domestic cat(101089941) ubiquitin protein ligase E3A
- cow(533136) ubiquitin protein ligase E3A
- Horse(100050725) ubiquitin protein ligase E3A
- Zebrafish(792398) ubiquitin protein ligase E3A
- fruit fly(39266) Ubiquitin protein ligase E3A
- chicken(418686) ubiquitin protein ligase E3A
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Antibodies
货号
说明
物种反应性
应用
Monoclonal Anti-UBE3A antibody produced in mouse, clone 3E5, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Anti-UBE3A antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-UBE3A Antibody, clone 1B9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human
应用
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-UBE3A Antibody, clone 10H7.1, clone 10H7.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-UBE3A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Proteins
货号
说明
物种
UBE3A active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥72% (SDS-PAGE),
物种
human
esiRNA
货号
说明
物种