TAB1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
别名:
3'-Tab1, MAP3K7IP1
物种:
Human TAB1 (10454), Mouse Tab1 (66513), Rat Tab1 (315139), dog TAB1 (481245), domestic cat TAB1 (101083606), cow TAB1 (519958), sheep TAB1 (101122943), naked mole-rat Tab1 (101696480), domestic guinea pig Tab1 (100735373), Domestic Rabbit TAB1 (100358246) ...展开
UniProtKB ID:
基因ID:
- Human(10454) Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(66513) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- Rat(315139) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- dog(481245) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- domestic cat(101083606) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- cow(519958) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- sheep(101122943) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- naked mole-rat(101696480) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- domestic guinea pig(100735373) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- Domestic Rabbit(100358246) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- Zebrafish(403084) TGF-beta activated kinase 1/MAP3K7 binding protein 1
- chicken(418014) TGF-beta activated kinase 1/MAP3K7 binding protein 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-phospho-TAB1 (Thr431) Antibody, from rabbit, purified by affinity chromatography,
物种反应性
equine, horse, human, mouse, ox, rat
应用
western blot
Anti-TAB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-TAB1 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-TAB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-TAB1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Proteins
货号
说明
物种
TAK1-TAB1 (1-303), (437-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
esiRNA
货号
说明
物种