SHANK3
SH3 and multiple ankyrin repeat domains 3
别名:
DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
物种:
Human SHANK3 (85358), Mouse Shank3 (58234), Rat Shank3 (59312), cow SHANK3 (512428), Horse SHANK3 (100056993), domestic cat SHANK3 (101085990), dog SHANK3 (474456), naked mole-rat Shank3 (101722405), chicken SHANK3 (101666327), chicken SHANK3 (101748950) ...展开
UniProtKB ID:
基因ID:
- Human(85358) Summary: This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
- Mouse(58234) SH3/ankyrin domain gene 3
- Rat(59312) SH3 and multiple ankyrin repeat domains 3
- cow(512428) SH3 and multiple ankyrin repeat domains 3
- Horse(100056993) SH3 and multiple ankyrin repeat domains 3
- domestic cat(101085990) SH3 and multiple ankyrin repeat domains 3
- dog(474456) SH3 and multiple ankyrin repeat domains 3
- naked mole-rat(101722405) SH3 and multiple ankyrin repeat domains 3
- chicken(101666327) SH3 and multiple ankyrin repeat domains 3
- chicken(101748950) SH3 and multiple ankyrin repeat domains 3
- Zebrafish(793484) SH3 and multiple ankyrin repeat domains protein 3
- domestic guinea pig(100723583) SH3 and multiple ankyrin repeat domains 3
- sheep(101119297) SH3 and multiple ankyrin repeat domains 3
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Antibodies
货号
说明
物种反应性
应用
Anti-SHANK3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-SHANK3 antibody produced in mouse, clone S72-16, 1 mg/mL, purified immunoglobulin,
物种反应性
human, mouse, rat
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Shank3 Antibody, clone 16E2.3, clone 16E2.3, from mouse,
物种反应性
human, mouse
应用
western blot
Anti-SHANK3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 antibody produced in mouse, clone S367-51, purified immunoglobulin,
物种反应性
mouse, rat
应用
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
esiRNA
货号
说明
物种