SHANK3
SH3 and multiple ankyrin repeat domains 3
Synonyms:
DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
Species:
Human SHANK3 (85358), Mouse Shank3 (58234), Rat Shank3 (59312), cow SHANK3 (512428), Horse SHANK3 (100056993), domestic cat SHANK3 (101085990), dog SHANK3 (474456), naked mole-rat Shank3 (101722405), chicken SHANK3 (101666327), chicken SHANK3 (101748950) ...More
UniProtKB ID:
Gene ID:
- Human(85358) Summary: This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
- Mouse(58234) SH3/ankyrin domain gene 3
- Rat(59312) SH3 and multiple ankyrin repeat domains 3
- cow(512428) SH3 and multiple ankyrin repeat domains 3
- Horse(100056993) SH3 and multiple ankyrin repeat domains 3
- domestic cat(101085990) SH3 and multiple ankyrin repeat domains 3
- dog(474456) SH3 and multiple ankyrin repeat domains 3
- naked mole-rat(101722405) SH3 and multiple ankyrin repeat domains 3
- chicken(101666327) SH3 and multiple ankyrin repeat domains 3
- chicken(101748950) SH3 and multiple ankyrin repeat domains 3
- Zebrafish(793484) SH3 and multiple ankyrin repeat domains protein 3
- domestic guinea pig(100723583) SH3 and multiple ankyrin repeat domains 3
- sheep(101119297) SH3 and multiple ankyrin repeat domains 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SHANK3 antibody produced in mouse, clone S72-16, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Monoclonal Anti-Shank1/Shank3 - Biotin antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 - Atto 488 antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 - Rpe antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Shank1/Shank3 - Percp antibody produced in mouse, clone S367-51, purified immunoglobulin,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
esiRNA
Product Number
Description
Species