PTPN12
protein tyrosine phosphatase, non-receptor type 12
别名:
PTP-PEST, PTPG1
物种:
Human PTPN12 (5782), Mouse Ptpn12 (19248), Rat Ptpn12 (117255), chicken PTPN12 (417725), cow PTPN12 (531877), sheep PTPN12 (101117497), Zebrafish ptpn12 (393642), Horse PTPN12 (100057833), domestic guinea pig Ptpn12 (100725572), domestic cat PTPN12 (101091096) ...展开
UniProtKB ID:
基因ID:
- Human(5782) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
- Mouse(19248) protein tyrosine phosphatase, non-receptor type 12
- Rat(117255) protein tyrosine phosphatase, non-receptor type 12
- chicken(417725) protein tyrosine phosphatase, non-receptor type 12
- cow(531877) protein tyrosine phosphatase, non-receptor type 12
- sheep(101117497) protein tyrosine phosphatase, non-receptor type 12
- Zebrafish(393642) protein tyrosine phosphatase, non-receptor type 12
- Horse(100057833) protein tyrosine phosphatase, non-receptor type 12
- domestic guinea pig(100725572) protein tyrosine phosphatase, non-receptor type 12
- domestic cat(101091096) protein tyrosine phosphatase, non-receptor type 12
- dog(483277) protein tyrosine phosphatase, non-receptor type 12
- Domestic Rabbit(100350817) protein tyrosine phosphatase, non-receptor type 12
- naked mole-rat(101697685) protein tyrosine phosphatase, non-receptor type 12
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Antibodies
货号
说明
物种反应性
应用
Anti-PTP-PEST Antibody, clone AG25, ascites fluid, clone AG25, from mouse,
物种反应性
human, mouse, rat
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-PTPN12 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTPN12 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Monoclonal Anti-Protein Tyrosine Phosphatase PEST antibody produced in mouse, clone AG25, purified immunoglobulin,
物种反应性
bovine, human, mouse, rat
应用
immunoprecipitation (IP)
western blot
western blot
Proteins
货号
说明
物种
PTPN12 (1-355), active, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human