PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
别名:
PP2C-DELTA, WIP1
物种:
Human PPM1D (8493), Mouse Ppm1d (53892), Rat Ppm1d (287585), domestic cat PPM1D (101089556), chicken PPM1D (417644), Horse PPM1D (100071325), naked mole-rat Ppm1d (101698863), dog PPM1D (612934), domestic guinea pig Ppm1d (100731559), cow PPM1D (514005)
UniProtKB ID:
基因ID:
- Human(8493) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
- Mouse(53892) protein phosphatase 1D magnesium-dependent, delta isoform
- Rat(287585) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- domestic cat(101089556) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- chicken(417644) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- Horse(100071325) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- naked mole-rat(101698863) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- dog(612934) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- domestic guinea pig(100731559) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- cow(514005) protein phosphatase, Mg2+/Mn2+ dependent, 1D
- sheep(101108932) protein phosphatase, Mg2+/Mn2+ dependent, 1D
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Antibodies
货号
说明
物种反应性
应用
Anti-PPM1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-PPM1D antibody produced in mouse, clone 4D1, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Anti-PPM1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
ANTI-PPM1D (CENTER) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human
应用
western blot